ID   A0A091ELJ3_FUKDA        Unreviewed;       681 AA.
AC   A0A091ELJ3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Extracellular calcium-sensing receptor {ECO:0000313|EMBL:KFO36456.1};
GN   ORFNames=H920_02083 {ECO:0000313|EMBL:KFO36456.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO36456.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO36456.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO36456.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
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DR   EMBL; KN121407; KFO36456.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091ELJ3; -.
DR   eggNOG; KOG1056; Eukaryota.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd06365; PBP1_pheromone_receptor; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR24061:SF529; VOMERONASAL 2, RECEPTOR 53-RELATED; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00592; CASENSINGR.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR   PROSITE; PS50805; KRAB; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFO36456.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        569..592
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          585..662
FT                   /note="KRAB"
FT                   /evidence="ECO:0000259|PROSITE:PS50805"
SQ   SEQUENCE   681 AA;  75120 MW;  6C6D7E9BA4C3E750 CRC64;
     MLACALLVSS VPMGWRLPGS SPRFERPGDV VLGGSFSILQ FHGVVRLDFR SLPAGLPSSR
     VSRWGYRVAQ CFVFAVEEIN RNPHLLPNLT LGFSIRNSGD SVHGALHETM SFLTGQEDPV
     PNYVCQSGPP RAALVGDTRS ALSVAMARLL GLYKFPQVSY SSTLPSLSDK TQFPSFLRTR
     ISDFMSSRAV TQLVLHLGCS WVIILAQDDD FGQQASALAA RELEEADICI EFHLPVPSQH
     SPEKISTVVQ KMLTSTATGV LVFLSNCNFM LILQRLLGVH LLGQVWVSEG LLHTALALAM
     PGISQVLQGA FGLLCHGSRV RGFPEFFANL HPTRTPEDMF LGRFWEATFG CRWPHRNSTV
     AGDIWLCSGR ESLRGHEHPF QSVSEMDIAY TAVYSVTHAL QDLLSCEGGD GVCTDLQHFQ
     PWQLLHPLRK VRFQTPDGTH IMFDANGDLV TTFDVFQGQQ SPEGQFHFVH IGTVDPHRSP
     GDRMMIHLKD GVQVPSSVCS TSCEPGSSQI PQQGAPHCCF ECRPCPEGQF ANQKDMQSCR
     QCPEELYPSQ TRDRCLPRTE TFLAFDEPLG LALTLVVLAL AGLACLVLGV FLRFRDTPVG
     WMCTLSLAIP VDVVPQFTTT RVWLEKESTG GHQIAKPDVI SLLEQGEEPW FVEPVHPRSS
     CPGKCQDEKR DDITGVNLVT I
//