ID A0A091EQB9_CORBR Unreviewed; 582 AA.
AC A0A091EQB9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819};
DE Flags: Fragment;
GN ORFNames=N302_12506 {ECO:0000313|EMBL:KFO59221.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO59221.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO59221.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO59221.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|ARBA:ARBA00003993}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573}.
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DR EMBL; KK718888; KFO59221.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091EQB9; -.
DR STRING; 85066.A0A091EQB9; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:KFO59221.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000052976};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 212..407
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 429..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO59221.1"
FT NON_TER 582
FT /evidence="ECO:0000313|EMBL:KFO59221.1"
SQ SEQUENCE 582 AA; 64322 MW; 834CEB68863BDEDB CRC64;
LFLLAVRGSE GLYMVNGPPS FTESTAFQRD SGKNCKAVAF SKDGSLFAWC NGEKVNVVNV
TRAELLHSFD LPKTVCLEFS PKNNVLATWQ AYATAKDGTA GVPNLQLHDL RTGKCLKSFM
QKKMQNWCPC WADDESICAR NVNNEVHFFE NNNFNTIANK LHLQKVSDFV LSPGAQPSKV
AVYVPGSKGA PSFVRLYQYP NFEGPQSALA NKSFFKADKV TMLWNKKATA VLVIASTEVD
KTGASYYGEQ TLHYVAANGE SAVVQLPKNG PIYDVSWSPN SAEFCAVYGF MPAKATVFNL
KCDPVFDFGT GPRNAVYYSP HGHILVLAGF GNLRGQMEVW DVKNYKLISK PVASDSTYFA
WCPDGEHIVT ATCAPRLRVS NGYKIWHYTG SVLHSYKVPS GEEMWQVFWQ PFLDGVFPEK
AVKYQAVPSE LPSAEPRPAQ AYRPPALRNK PVTSSKLHED EPPQNMKPHL GSSDKPLSKT
ALKNQRKHEA KKAAKQEAKA DANQGPAQDK TPQNALQNAV PAMTTGDPEV DKKIKNLKKK
LKAIEQLKEQ AAAGKQLEKN QVEKIQKEAA LLKELEDLEL GV
//