ID A0A091FA64_CORBR Unreviewed; 726 AA.
AC A0A091FA64;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Histone-lysine N-methyltransferase SETDB2 {ECO:0000256|ARBA:ARBA00040299};
DE EC=2.1.1.366 {ECO:0000256|ARBA:ARBA00039052};
DE AltName: Full=SET domain bifurcated 2 {ECO:0000256|ARBA:ARBA00042995};
DE Flags: Fragment;
GN ORFNames=N302_05086 {ECO:0000313|EMBL:KFO58720.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO58720.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO58720.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO58720.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-
CC methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]
CC + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60288, Rhea:RHEA-
CC COMP:15538, Rhea:RHEA-COMP:15541, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961,
CC ChEBI:CHEBI:61976; EC=2.1.1.366;
CC Evidence={ECO:0000256|ARBA:ARBA00036635};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KK718821; KFO58720.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091FA64; -.
DR STRING; 85066.A0A091FA64; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd01395; HMT_MBD; 1.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR047232; SETDB1/2-like_MBD.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB2; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Methyltransferase {ECO:0000313|EMBL:KFO58720.1};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000052976};
KW Transferase {ECO:0000313|EMBL:KFO58720.1}.
FT DOMAIN 283..357
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 360..701
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 68..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..555
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO58720.1"
FT NON_TER 726
FT /evidence="ECO:0000313|EMBL:KFO58720.1"
SQ SEQUENCE 726 AA; 81354 MW; 0A358EE96E00BE47 CRC64;
DVKTFWTQLG GRRVDVIFEQ VQNVLLLLKE KIKNGTATNQ ECWQAWALVN EANLGDLLTL
ANVSDELNGD GAQETEPKLQ PLSDDSAADT KESSDSFFSS FTPNSKKEDM ERTCPGSEEV
SSKIQGLPLN VHYQNHKCSS ACLANRAAGS YKGENPLKIP ILFDFQRRHA KADCLSKSLD
VNYKAPCGRS LRSFRDVRNY LFETECNFLF LDHFSFNTYV LLGRNTMTPE PLVFEFDISN
GAESVPVSFC NTLDHARLPY FKYRKSSWPR GYYLNNFSSL FVDSCDCTDG CIDRSKCACL
QLTARGCSKT SLSPGGKRCR GYRYKRLEGP VPSGIYECSV LCRCDKLMCQ NRVVQHGIQV
RLQVFNTEKK GWGVRCLDDI DRGTFVCTYS GRLMSRAEVL RDAEQELKEK GAVNDRGHDF
SSKKRKLDPD SSDSVIELVQ TDENDIPENE ESLSKTVVNE NKSTLVHPKN SSNAAVRRPG
TRTLVFRNHQ LKMVISGFNR FIFYCAEYVS FSFDTQVHSA SSDEDDSSQI HQSSKTKLTS
GTKKGKEKST QQQKEEHLME IGQTGSADVD SAGCKRKSLS LQGIDCGKSG VLNDMCIVRP
SNNAPLKADC KKENSRQSKQ DALCEEADGD GMLPKNANEE NIYVLDATKE GNVGRFLNHS
CCPNLFAQSV FVETHNRSFP WVAFFTNRHV KAGTELTWDY GYEAGSMPET EISCQCGVQK
CRKKTL
//
