ID A0A091FIW7_CORBR Unreviewed; 1100 AA.
AC A0A091FIW7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Sterol regulatory element-binding protein 2 {ECO:0000256|ARBA:ARBA00039750};
DE AltName: Full=Sterol regulatory element-binding transcription factor 2 {ECO:0000256|ARBA:ARBA00042214};
DE Flags: Fragment;
GN ORFNames=N302_12764 {ECO:0000313|EMBL:KFO61330.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO61330.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO61330.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO61330.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SREBP family.
CC {ECO:0000256|ARBA:ARBA00038460}.
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DR EMBL; KK719069; KFO61330.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091FIW7; -.
DR STRING; 85066.A0A091FIW7; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18922; bHLHzip_SREBP2; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR46062; STEROL REGULATORY ELEMENT-BINDING PROTEIN; 1.
DR PANTHER; PTHR46062:SF3; STEROL REGULATORY ELEMENT-BINDING PROTEIN 2; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000052976};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 278..328
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 23..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..86
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO61330.1"
FT NON_TER 1100
FT /evidence="ECO:0000313|EMBL:KFO61330.1"
SQ SEQUENCE 1100 AA; 119839 MW; AD6AFB9227F07C11 CRC64;
EMLQFVSNQA GDFPDLFSDP LCSTFQGGSG SGSSSGTLEP QLQRPYSQVQ LQTFPPPPAS
PQLQSLPVKA AQTTPPAPPR SAPVLQPRPS LQPQLQQQAV MITPTFSSAP QTRIIQQPVI
YQNAATSFQV LQPQVQSLVT SSQVQPVTIQ QQVQTVQAQR VLTQAANGTI QTLTPATVQT
VAAPQVQQVP VLVQPQIIKT DSLVLTTLKT DGNPVMAAVQ NPALTALTAP IQTTALQTLV
GSNGTILTTM PVMVGQEKVP IKQVPGGVKQ PEPPKEGERR TTHNIIEKRY RSSINDKIIE
LKDLVMGTDA KMHKSGVLRK AIDYIKYLQQ ANHKLRQENM VLKLANQKNK LLKGIDLSSL
VDNDVDLKID DFNQNVLLMS PPASDSGSQA GFSPYSIDSE PGSPLLDDAK VKDEPDSPPV
ALGMVDRSRI LLCALTFLCL SFNPLTSLLD ARGTPESDSL VRHGSGRNVL TIESDAAGWF
GWMMPTLILW LVNGVIVLSV FIKLLVHGEP VTRLHSRSSV TFWRHRKQAD LDLARGDFAA
AASNLQTCLS VLGRALPASR LDLACSLSWN VIRYSLQKLA LVRWLLKRTS HQWRAREATA
GFEDEAKTSA RDAALAYHKL HQLHITGKLP SSSAYSGLHM ALCAVNLAEC AEEKIPPSTM
AEIHLTAAVG LKTRCGGKLG FLASYFLSQA QSLCSSERSA IPDSLRWLCH PLGQKFFVER
SWTVKSAAKE SLYCTQRNPA DPIAQVHQAF CENLLERAVD SLVKPQTRKD VAGQEEEESC
EFSGAMEYLK LLNSFLDSMG SGAPPFASNS LLKSALGPDV VCRWWSAAVA MAIAWLRGDD
AAVRSHFAEV ERMPKSLEMS DMTWYCLKAA CFLALVKATF YMCKAMQASL SGKADGQQSS
LGHCERASSH LWNSLNMSSG TSSTVLNNMI QLLACALLLS LRTSLWQKQA NASQALGETY
HASAPELTGF QRDLGSLRKL AHSFRPAYRK VFLHEATVRL MAGASPTRTH QLLEHSLRRR
TPQSSKQGEL DTLPGQRERA TAILLACRHL PLSFLSSPGQ RAVLLAEAAR TLEKVGDKRS
CNDCQQMIVK LSGGTAIAAS
//
