ID   A0A091FJK2_9AVES        Unreviewed;       749 AA.
AC   A0A091FJK2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=DNA mismatch repair protein Mlh1 {ECO:0000313|EMBL:KFO69289.1};
GN   ORFNames=N303_06636 {ECO:0000313|EMBL:KFO69289.1};
OS   Cuculus canorus (common cuckoo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX   NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO69289.1, ECO:0000313|Proteomes:UP000053760};
RN   [1] {ECO:0000313|EMBL:KFO69289.1, ECO:0000313|Proteomes:UP000053760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO69289.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
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DR   EMBL; KL447035; KFO69289.1; -; Genomic_DNA.
DR   RefSeq; XP_009556932.1; XM_009558637.1.
DR   AlphaFoldDB; A0A091FJK2; -.
DR   STRING; 55661.A0A091FJK2; -.
DR   GeneID; 104057262; -.
DR   KEGG; cuca:104057262; -.
DR   CTD; 4292; -.
DR   OrthoDB; 5475669at2759; -.
DR   Proteomes; UP000053760; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03483; MutL_Trans_MLH1; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR032189; Mlh1_C.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF16413; Mlh1_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053760}.
FT   DOMAIN          213..332
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   REGION          396..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   749 AA;  83815 MW;  F9CFBD394FE3ABE2 CRC64;
     MAGAIRRLDE AVVNRIAAGE VIQRPANAIK EMIENCLDAK STSIQVVVKE GGLKLIQVQD
     NGCGIRKEDL DIVCERFTTS KLQKFEDLAS ISTYGFRGEA LASISHVAHV TVTTKTADAK
     CAYRASYSDG KIKAPPKPCA GNQGTQITVE DLFYNVNTRR KALKNPNEEY AKILEVVGRY
     AIHNSGISFS VKKQGDTVSD IRTLSNASTV DNIRSIFGNA VSRELIEVGC EDASLAFKMK
     GYITNANYSV KKCTFLLFIN HRLVESAALR KAIETVYAAY LPKSTHPFLY LSLEITPQNV
     DVNVHPTKHE VHFLHEDSIL ERVQQHIESK LLGSNSSRMY FTQTLLPGAE CSSSEAVKPA
     ANTSASTKGT SDKVYAHQMV RTDSREQKLD AFLQPVNNPL STGPTEVTTE VNAGPPEGAV
     RPQDAEMEDV SDVIEMANVQ EDAVKPGGLS ESGHLSPEKA PPRKRLREDM DIEMEKDDTR
     KDMTAACTPR RRIINLTSVL TLQEEISNQA HASLQEMLHD HSFVGCVSPQ WALAQYQTKL
     YLLNTTKLSQ ELFYQILIYD FANFGVLRLS EPAPLYELSM LALEDPESGW TEEDGPKEGL
     AEYIVEFLKK KTEMLKDYFS LEIDEEGNLI GLPLLIDNYV PPLEGLPMFI LRLATEVNWD
     EEKECFESLS KELAMFYSIR KQYITDEANL TDSQNEDSNS GSKTWKWTVE HVLYKAFRTH
     LLPPKHFTED GNILQLANLP DLYKVFERC
//