ID A0A091FMJ2_9AVES Unreviewed; 598 AA.
AC A0A091FMJ2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Paxillin {ECO:0000256|ARBA:ARBA00023808};
DE Flags: Fragment;
GN ORFNames=N303_09727 {ECO:0000313|EMBL:KFO70359.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO70359.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO70359.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO70359.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the paxillin family.
CC {ECO:0000256|ARBA:ARBA00005813, ECO:0000256|PIRNR:PIRNR037881}.
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DR EMBL; KL447166; KFO70359.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091FMJ2; -.
DR STRING; 55661.A0A091FMJ2; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005925; C:focal adhesion; ISS:AgBase.
DR GO; GO:0005886; C:plasma membrane; ISS:AgBase.
DR GO; GO:0001725; C:stress fiber; ISS:AgBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017166; F:vinculin binding; ISS:AgBase.
DR CDD; cd09336; LIM1_Paxillin_like; 1.
DR CDD; cd09407; LIM2_Paxillin; 1.
DR CDD; cd09338; LIM3_Paxillin_like; 1.
DR CDD; cd09411; LIM4_Paxillin; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR InterPro; IPR047072; Paxillin_Lim_dom2.
DR InterPro; IPR001904; Paxillin_Lim_dom4.
DR InterPro; IPR047075; Paxillin_TGFB1I1_LIM_dom1.
DR InterPro; IPR017305; Tgfb1i1/Leupaxin/TGFB1I1.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24216:SF11; PAXILLIN; 1.
DR PANTHER; PTHR24216; PAXILLIN-RELATED; 1.
DR Pfam; PF00412; LIM; 4.
DR Pfam; PF03535; Paxillin; 1.
DR PIRSF; PIRSF037881; Leupaxin; 2.
DR PRINTS; PR00832; PAXILLIN.
DR SMART; SM00132; LIM; 4.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 5.
DR PROSITE; PS00478; LIM_DOMAIN_1; 3.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PIRNR:PIRNR037881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 363..422
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 423..480
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 481..540
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 541..598
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 1..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO70359.1"
FT NON_TER 598
FT /evidence="ECO:0000313|EMBL:KFO70359.1"
SQ SEQUENCE 598 AA; 65650 MW; 06D36DB523F34824 CRC64;
DALLADLEST TSHISKRPVF LTEETPYSYP TGNHTYQEIA VPPPVPPPPS NEALNGTVID
PLDQWQPSVS RYTHQQPQSQ SPIYSSSAKS SSASIPRDGL SSPSPRASEE EHVYSFPNKQ
KSAEPSPTMT SSSLGSNLSE LDRLLLELNA VQHNPAGGFP ADEASRSPSL PSLTGPHYVV
PEGSSSVGGK AAPPTKEKPK RNGARGIEDV RPSVESLLDE LESSVPSPVP AITVSQGEVS
SPQRVTASQQ QTRISASSAT RELDELMASL SDFKVPYHHN LMLCLFPPHS CPWFFLLNPH
SPQGGRTCLT VFVFSSLQFM AQGKAGSSSP PSTASKPGSQ LDTMLGSLQS DLNKLGVATV
AKGVCGACKK PIAGQVVTAM GKTWHPEHFV CTHCQEEIGS RNFFERDGQP YCEKDYHNLF
SPRCYYCNGP ILDKVVTALD RTWHPEHFFC AQCGAFFGPE GFHEKDGKAY CRKDYFDMFA
PKCGGCARAI LENYISALNT LWHPECFVCR ECFTPFVNGS FFEHDGQPYC EVHYHERRGS
LCSGCQKPIT GRCITAMGKK FHPEHFVCAF CLKQLNKGTF KEQNDKPYCQ NCFLKLFC
//
