ID A0A091FP78_9AVES Unreviewed; 946 AA.
AC A0A091FP78;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Insulin-degrading enzyme {ECO:0000313|EMBL:KFO70974.1};
DE Flags: Fragment;
GN ORFNames=N303_09159 {ECO:0000313|EMBL:KFO70974.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO70974.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO70974.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO70974.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; KL447250; KFO70974.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091FP78; -.
DR STRING; 55661.A0A091FP78; -.
DR MEROPS; M16.984; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 36..172
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 199..377
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 383..660
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 664..847
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO70974.1"
FT NON_TER 946
FT /evidence="ECO:0000313|EMBL:KFO70974.1"
SQ SEQUENCE 946 AA; 109515 MW; B3910B1C86CC138A CRC64;
NKMNNPAIKR ITNEIIKSPE DKREYRGLEL ANGIKALLIS DPTTDKSSAA LDVHIGSLSD
PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN AFTSGEHTNY YFDVSHEHLE
GALDRFAQFF LCPLFDESCK DREVNAVDSE HEKNLMNDAW RLFQLEKATG NPSHPFSKFG
TGNKLTLETR PTKEGIDVRE ELLKFHSTYY SSNLMAICVL GRESLDELTC LVVKLFSEVE
NKNVPVPEFP EHPFQEEHLR QLYKVVPIKD IRNLYVTFPI PDLQKYYKSN PGHYLGHLIG
HEGPGSLLSE LKAKGWVNTL VGGQKEGARG FMFFIINVDL TEEGLLHVED IILHMFQYIQ
KLRTEGPQEW VFQECKDLNA VAFRFKDKER PRGYTSKLGG MLHYYPIEEV LAAEYLLEEF
RPDLIEMVLD KLRPENVRVA IVSKSFEGKT DRTEDWYGTQ YKQEAISDEK WQNADLNGKF
KLPMKNEFIP TNFEILPLEK DATQYPALVK DTAMSKLWFK QDDKFFLPKA CLNFEFFSPF
AYVDPLHCNM AYLYLELLKD SLNEYAYAAE LAGLNYDLQN TIYGMYLSVK GYNDKQHILL
KKIIEKMATF EIDEKRFEII KEAYMRSLNN FRAEQPHQHA MYYLRLLMTE VAWTKDELKE
ALDDVTLPRL KAFIAQLLSR LHIEALLHGN ITKQAALGIM QMVEDTLIEH AHTKPLLPSQ
LVRYREVQLP DRGWFVYQQR NEVHNNCGIE IYYQTDMQST SENMFLELFC QIISEPCFNT
LRTKEQLGYI VFSGPRRANG IQGLRFIIQS EKPPHYLESR VEAFLKTMEK CIEDMTEEAF
QKHIQALAIR RLDKPKKLSA ECAKYWGEII SQQYNFDRDN IEVAYLKTLT KDDIIQFYKV
LLAIDAPRRH KVSVHVLARE MDSCPVVGEF PCQNDVNLAP APPLPQ
//