ID A0A091FRH0_9AVES Unreviewed; 690 AA.
AC A0A091FRH0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=IkappaB kinase {ECO:0000256|ARBA:ARBA00012442};
DE EC=2.7.11.10 {ECO:0000256|ARBA:ARBA00012442};
DE Flags: Fragment;
GN ORFNames=N303_05453 {ECO:0000313|EMBL:KFO71576.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO71576.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO71576.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO71576.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-
CC seryl-[I-kappa-B protein]; Xref=Rhea:RHEA:19073, Rhea:RHEA-
CC COMP:13698, Rhea:RHEA-COMP:13699, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC ChEBI:CHEBI:456216; EC=2.7.11.10;
CC Evidence={ECO:0000256|ARBA:ARBA00023939};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KL447267; KFO71576.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091FRH0; -.
DR STRING; 55661.A0A091FRH0; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008384; F:IkappaB kinase activity; IEA:UniProtKB-EC.
DR CDD; cd17046; Ubl_IKKA_like; 1.
DR Gene3D; 1.20.1270.250; -; 1.
DR Gene3D; 6.10.250.2110; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041185; IKBKB_SDD.
DR InterPro; IPR046375; IKBKB_SDD_sf.
DR InterPro; IPR022007; IKKbetaNEMObind.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR PANTHER; PTHR22969:SF7; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA; 1.
DR Pfam; PF18397; IKBKB_SDD; 1.
DR Pfam; PF12179; IKKbetaNEMObind; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM01239; IKKbetaNEMObind; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFO71576.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..233
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT COILED 463..513
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO71576.1"
FT NON_TER 690
FT /evidence="ECO:0000313|EMBL:KFO71576.1"
SQ SEQUENCE 690 AA; 79389 MW; 169EBCDE6F350884 CRC64;
RLNHPNVVAA RDVPEGMQKL APNDLPLLAM EYCQGGDLRK YLNQLENCCG LREEAILILL
SDIASALRYL HENRIIHRDL KPENIVLQQG EQRLIHKIID LGYAKELDQG SLCTSFVGTL
QYAPELLEQQ KYTVTVDYWS FGTLAFECIT GFRPFLPNWQ PVQWHTKVRQ KSELDIVVSE
DLSGEVKFSS SLPCPNNLNS VLAGRLEKWL QLMLMWHPRQ RGTDPTYGPY GCFKALDDIL
NLKLLHVLNM VTGTVHTYPV TEEDTLQTLK ARIQSDTGIP EQDQELLQEA GLELFSQKLA
TKHIADSKVN DTAAADTDLL FLFDNQKVAY EAQVALRPHP ESVDCILQDP KKNLHFFQLR
KVWGQIWHTI RMLKEDCNRL QQGQRAAMMN LLRYNSTLSK MKNSMASLSQ QLKAKLDFFK
TSIQIDLEKY KEQIEFGITS EKLLFAWKEM EQAVELCGRE DDVDQLVKRM MALQTDIVDL
QRSPLGRKQG GTLEDLEEQA RELYRRLREK PRDQRTSGDS QEIVRLLLQA IQAFEKKVRV
IYAQLSKTVV CKQKALELFP RVEKVMNLMN EDEETVVRLQ EKRQKELWNL LKIACSKVRG
PVTGSPESMN TSRLGSPGHL MLQVPSGTYN LSESVRKSEE LLLESQKLCS QLENVMRDTM
KDQEQSFMAL DWSWLQLHTE EPNSPEQTQM
//
