ID A0A091FRL1_9AVES Unreviewed; 999 AA.
AC A0A091FRL1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 40.
DE SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|EMBL:KFO72248.1};
DE Flags: Fragment;
GN ORFNames=N303_07230 {ECO:0000313|EMBL:KFO72248.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO72248.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO72248.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO72248.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL447299; KFO72248.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091FRL1; -.
DR STRING; 55661.A0A091FRL1; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760}.
FT DOMAIN 22..125
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 197..272
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 337..438
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 477..622
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 760..997
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO72248.1"
FT NON_TER 999
FT /evidence="ECO:0000313|EMBL:KFO72248.1"
SQ SEQUENCE 999 AA; 114784 MW; 02648EA9F961F315 CRC64;
RPLERSSEDV DIIFTRLKEV KAFEKFHPNL LQQICLCGYY ENLEKGVTLF RQGDIGTNWY
AVLTGSLDVK VSDTSNHQDA VTICTLGIGT AFGESILDNT PRHATIVTRE YSELLRIEQK
DFKALWEKYR QYMSGLLTPP YGVMETGSNN DNFEIMFKKE TPLIEPHIPH RPTKTITQVP
SEKILRAGKI LRNTILSRAP HMIRDRKYHL KTYRQCCVGT ELVDWMMQQS PCVHSRTQAV
GMWQVLVEEG VLNHVDQEHH FQDKYLFYRF LDDEREDAPL PTEEEKKECD EEIQDTMLLL
SQIGPDAHMR MILRKPPGQR TVDDLEIIYE ELLHIKALSH LSTTVKRELA GVLIFESHPK
AGTVLFNQGE EGTSWYIILK GSVNVVIYGK GVVCTLHEGD DFGKLALVND APRAASIVLR
EDNCHFLRVD KEDFNRILRD VEANTVRLKE HDQDVLVLEK IPAGNRVSNQ GNSQPQHKYI
VMSGTPEKIL EHFLETMRLD TTLNEATDSG LNDFIMMHCV FMPNIQLCPA LMAQYPFHYG
TYHAQPSQGT EQEKMDYALN NKRRVIRLVL QWAALYGDLL QEDEAAMAFL EEFYVSVSDD
TRMIAALKEQ LPELEKIVKQ VSEEPKASQK KHKVLLQLFN TNDDRAQKRL PIRGSDEVLF
KVYCIDQTYT TIRVPVSSSV KEVISAVADK LGSGEGLIIV KMSSGGEKVV LKPHDVSVFT
TLTVNGRLFA CPRDQFDSLT PLPEQEGPST GTVGTFELMS SKDLAHQMTI YDWELFNCMH
ELELIYHTFG RHNFKKTTAN LDLFLRRFNE IQFWVVTEIC LCSQLSKRVQ LLKKYIKIAA
HCKEYKNLNS FFAIIMGLSN VAVSRLSLTW EKLPSKFKKI YAEFESLMDP SRNHRAYRLT
VAKLEPPIIP FMPLLIKDMT FTHEGNKTFT DNLVNFEKMR MIANTVRTVK FCRSQSFNPD
AALTNKNHQD VRSYVRQLNV IDNQRTLSQM SHRLEPRRA
//
