ID A0A091FU54_9AVES Unreviewed; 1669 AA.
AC A0A091FU54;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
DE Flags: Fragment;
GN ORFNames=N303_09577 {ECO:0000313|EMBL:KFO72531.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO72531.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO72531.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO72531.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
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DR EMBL; KL447350; KFO72531.1; -; Genomic_DNA.
DR STRING; 55661.A0A091FU54; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd00084; HMG-box_SF; 1.
DR CDD; cd02735; RNAP_I_Rpa1_C; 1.
DR CDD; cd01435; RNAP_I_RPA1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.357.120; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.70.2850; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR047107; DNA-dir_RNA_pol1_lsu_C.
DR InterPro; IPR015699; DNA-dir_RNA_pol1_lsu_N.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 270..617
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 1346..1439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1378
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1379..1394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1412
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1425..1439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO72531.1"
FT NON_TER 1669
FT /evidence="ECO:0000313|EMBL:KFO72531.1"
SQ SEQUENCE 1669 AA; 188804 MW; 98DCD436E2715E10 CRC64;
RKLSVKLITN PQYLDNVGNP AANGLYDLAL GPPDSKEVCA TCMQNFTNCP GHFGHIELPL
TVYNPLFFDK LYLLIRGSCL NCHMLTCTRA VVHLLLSQLK VLEKGLLHAV HDLEVILNRA
KQCADATGSE IEEELNNHVQ EMLQSYQMKD QCSNVKNVCE CRNKLIAQFW KAHMSSKKCP
NCKSRRSLVR KEHNSKLTVT YPSTVYHKLG EGVVLDEPAA IDESQLGKRG YLTPMTAKEY
IQALWKNEGF FLRYLFPGTD PHDSSGFNPD MFFLDLLVVP PSRYRPVNRV GDRLFTNGQT
VNLQAVMKDA KMIRKLLVFM AKEQCQPIKI TEEEIQTETG ENNEPLDHSF LTTIPGQTLA
DKLYNAWIRL QTHVNIVFDS DMDKLMTEKY PGIRQLLEKK EGLFRKHMMG KRVDFAARSV
ICPDMYIGTN EIGIPMVFAT KLTYPQPVTP WNVKELRQAV INGPKVHPGA SMVINEDGSR
TVLSASSLTQ REAIAKQLLT PSSGAPQTGL KIVCRHIKNG DVLLLNRQPT LHRPSIQAHR
ARILPGEKVL RLHYANCKAY NADFDGDEMN AHFPQSELGR AEAYTLAFTD EQYLVPKDGK
PLPGLIQDHM ISGVSMTIRG CFFTREQYME LVYRGLTDKK GRIKILPPAI MKPQRLWTGK
QVVSTLLINI IPENHIPLNL TGKAKIGGRA WVKGPAKRCL NLDSMCESQV IIRSGELLCG
VLDKAHFGSS AYGLVHCCYE IYGGGTSGTV LTCLGRLFTA YLQLYRGFTM GIEDILVKHE
ADQKRQKIIE ESSQHGIEAV RAALNLPETA SCEEVQGKWQ NAHLCKDQRD FNMVDLKFKE
EVNNYNNEVN KVCMPLGLHR RFPENNLQLM VQSGAKGSTV NTMQISCLLG QIELEGRRPP
LMASGKSLPC FQPYDFSPSS GGFVTGRFLT GIKPSEFFFH CMAGREGLVD TAVKTSRSGY
LQRCIIKHLE GLVVQYDLTV RDSDGSVVQF LYGEDGLDIP KTQFLQPEQF PFIAENYEVI
QKTSHLDEAL ARMESHQATQ HFKAIKKWRA RHQNSLQREG GFLMFARKKM ASVKARIPGG
EMKNGRDPAT LQLLKMWYEL DEKKRRKYTK KANKCPDPSL GVWRPDTYFA SVSETFGSGV
EDYINKWESE NRQSYTQPTL SSDRLKDLLY LKWQRSLCDP GEAVGLLAAQ SIGEPSTQMT
LNTFHFAGRG EMNVTLGIPR LREILMVASA NIKTPTMSVP VFNTKKALKK VKQLKKLLTR
VCLAEVLQKV EIEESLRVKC KQDKHHLYKI KFHFLPHEYY KEEKCVKPRE ILHFMETRFF
KIFLEAIKKK NAKMTSFTEI STRKATRKDL DGDQDKNDQE APAEEEENIV DAEADEGDGD
ATEAKRRRNQ EEEEANIDEN QEDEEAESEK EKTPDAEEDQ NGAGGDDSQP LSFVSQSKKE
KNRLLQSMDL RINAVLDSHP SIQDYTFDTE NELWCEVSLA IPLMKVYFDL SSLLVSLARS
TVIHEVKGIT RCLLNESTNK QGEKELILHT EGINLAEMFR YSDILDLNRL YSNDIHAMAK
NYGIESALRA IIKEIKDVFA VYGIVVDPRH LSLVADYMCF EGFYKPLNRF GIQSNSSPLQ
QMTFETSYKF LKEATMMGAH DELRSPSACL VVGKVVKGGT GLFDLKQPL
//
