ID A0A091FVL3_9AVES Unreviewed; 1325 AA.
AC A0A091FVL3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
DE Flags: Fragment;
GN ORFNames=N303_14885 {ECO:0000313|EMBL:KFO73688.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO73688.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO73688.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO73688.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104,
CC ECO:0000256|RuleBase:RU367118}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR EMBL; KL447467; KFO73688.1; -; Genomic_DNA.
DR STRING; 55661.A0A091FVL3; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004970; F:glutamate-gated receptor activity; IEA:UniProt.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IEA:UniProt.
DR CDD; cd13718; PBP2_iGluR_NMDA_Nr2; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR018884; NMDAR2_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF407; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF10565; NMDAR2_C; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 416..438
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 488..510
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 679..702
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 290..657
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 298..361
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 877..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO73688.1"
FT NON_TER 1325
FT /evidence="ECO:0000313|EMBL:KFO73688.1"
SQ SEQUENCE 1325 AA; 151179 MW; D9A705C47BF716BD CRC64;
STFFQFGASI QQEAIVMLKI MQDYDWHVFS LVTTTFPGYR DFINVIKTTV DNSFVGWDMQ
NIIILDTAFG DAKTQIQLKK IHSSVILLYC SKDEAVYILD EARSLGLTGY DYFWIVPSLV
SGNTEITPKE FPSGLISASY DEWDYSLEAR VRDGLGIIAT AASAMLEKYS FIPEAKTSCY
GQLEKNDRPS QTLHKFMMNV TWEGKDLSFT ADGYQAHPRL VVIVLNNDRE WEKVGKWENN
SLSLKYSVWP RYSSFADSDP DDNHLSIVTL EEAPFVVVED VDPLMESCQK NTVPCRKFVK
INNSTNEGIN VKKCCKGFCI DILKKLSKTV KFTYDLYLVT NGKHGKKVNN VWNGMIGEVV
YHRAVMAVGS LTINEERSEV VDFSVPFVET GISVMVSRSN GTVSPSAFLE PFSASVWVMM
FVMLLIVSAM AVFIFEYFSP VGYNRNLAQG RDPHGPSFTI GKAVWLLWGL VFNNSVPVQN
PKGTTSKIMV SVWAFFAVIF LASYTANLAA FMIQEEFVDQ VTGLSDKKFQ RPYDYSPPFR
FGTVPNGSTE RNIRNNYPDM HLYMTKYNQK GVEDALVSLK TGKLDAFIYD AAVLNYKAGR
DEGCKLVTIG SGYIFATTGY GIALQKGSPW KRQIDLALLQ FVGDGEMEEL ETLWLTGICH
TEKNEVMSSQ LDIDNMAGVF YMLAAAMALS LITFVWEHLF YWKLRFCFTG VCSDRPGLLF
SISRGIYSCI HGVHIEEKKK SPDFTLTNSQ TNMLKLLRTA KNMTNINSSR INSPKRTADF
IQRGSLIMDM VMDKGNLIFS DNRSFQTKDN YFGDNMSELQ TLPGNRHKDN LNNYVFQGQH
PLTLNESNPN TVEVAVTTEA KVNSRPRQLW RKSVESLRQE SLRQESVRQS QGSQRENGSD
ETRQLSVKSQ RYLPEEIVHS DVSETSSRAT CHMEPENNNK HHKTKDNFKK RTVPSKYPKD
CSEVELTYLK TKQSSPRDKI YTIDADKEPG FRLDTPQYIE NIVLPETIEL PDVYQDHNDN
YRKAEHANRT PLHNEDSLPN NDQYKLYAKH YTLKDKNASL GDMNDRYRQN STHCRSCLSN
VPTYAGHYSS RSPYKCDACL RMGNLYDIEE DQMLQDTTNL SLPEEIYEHS WSQNNALQYH
KKNKLRISRQ HSFDNIADKS REIDIGRPSR SISLKEREKF LQSSPYASMF SVPSSKLLSN
KASLLTHALE DSKRSKSLYP VHSDDNPFLH SYRDDQHLSL RRSPADLYKY SLPTRGRNDN
YLRSSIKSTA SYCSRDGRVH NDMYISEHVL PYVANRNSLY STPRVLNSCS NRRVYKKMPS
IESDV
//
