ID A0A091FZS5_9AVES Unreviewed; 634 AA.
AC A0A091FZS5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 24.
DE SubName: Full=Protein-glutamine gamma-glutamyltransferase E {ECO:0000313|EMBL:KFO74294.1};
DE Flags: Fragment;
GN ORFNames=N303_13176 {ECO:0000313|EMBL:KFO74294.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO74294.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO74294.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO74294.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; KL447510; KFO74294.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091FZS5; -.
DR STRING; 55661.A0A091FZS5; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR013808; Transglutaminase_AS.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF36; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE E; 1.
DR Pfam; PF00927; Transglut_C; 1.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Transferase {ECO:0000313|EMBL:KFO74294.1}.
FT DOMAIN 256..348
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT ACT_SITE 264
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 322
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 345
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 385
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 387
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 435
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 440
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO74294.1"
FT NON_TER 634
FT /evidence="ECO:0000313|EMBL:KFO74294.1"
SQ SEQUENCE 634 AA; 70919 MW; 3AA8B555701AACFE CRC64;
INWHLKENAR DHHTSKFSSK ELTVRRGQPF TVTFNGIEEA EQNLTFIAET GPKPSKPAKT
EVTFGISSTV SKESWSAVLQ STTSNSVSIS ISSPPNAIIG RYKLSVRSTA RGSSSPASLG
TFVLLFNPWS SGDDVFLSNK AECEEYVLEE FGIIFAGNKN HINSFGWNFG QFQEDILNIC
LSMLDRSLNY RQDPVTDVSH RNDPKYVGRV LSAMVNANDD HGVLLGNWSG NYDGGKSPSS
WTGSVEILQG WKKSGFKPVK YGQCWVFAAV LTTVLRCLGI PTRTITNFSS AHDADGNLRV
DEFYDADGNH LDRAADSIWN FHVWNESWFS RSDLGPSYSG WQVLDATPQE ESEGIYQCGP
ASRHAIKEGD VDLDYDCPFV FAEVNADCMY WNYDPATRKK TLIFSKSTEI GQSISTKAVG
RDDRVDVTND YKYEEGSKKE RDIFKKARKK LGLEDKFDPT APTQEEIDQK PDISGKFKVA
GSFEVGKDLN LILILENLQS DAKTVHVNMT AWTTVYTRKP VYEIWKDSIS VTLSPKEEKQ
FPIKISYPEY QQQLTTDKMI QVTALCHVEG GIQVLVQRDI TLDNPAVDIQ VLGEAKVNKE
VDVEVIFTNT IDVEVKDCVL HVQGNDLLRG ILEI
//
