ID A0A091G190_9AVES Unreviewed; 1191 AA.
AC A0A091G190;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=N303_07620 {ECO:0000313|EMBL:KFO75121.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO75121.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO75121.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO75121.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649}.
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DR EMBL; KL447600; KFO75121.1; -; Genomic_DNA.
DR RefSeq; XP_009557787.1; XM_009559492.1.
DR AlphaFoldDB; A0A091G190; -.
DR STRING; 55661.A0A091G190; -.
DR KEGG; cuca:104058036; -.
DR OrthoDB; 3108587at2759; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR CDD; cd17099; FERM_F1_PTPN14_like; 1.
DR CDD; cd14599; PTPc-N14; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF6; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 14; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Receptor {ECO:0000313|EMBL:KFO75121.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760}.
FT DOMAIN 21..306
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 913..1184
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1094..1175
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT ACT_SITE 1125
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ SEQUENCE 1191 AA; 135677 MW; DC4DC221A66BB790 CRC64;
MPFGLKLRRT RRYNVLSKNC FVTRIRLLDN NAIECTLSVE STGQECLEAV AQRLELRETH
YFGLSFLSKS QQARWVELEK PLKKQLDKFA NEPLLFFGVM FYVPSVSRLQ QEVTRYQYYL
QVKKDVLDGR LLSSLEQRIR LAGLAVQADF GDYNQFESHD FLREYVLFPM DWTQDEAVLE
ELIQKVAQEH RTHSGLTAAE AELMYINEVE RLDGFGQEFF PVRDNHGNDI RLGIFFMGIF
IKNRIGRTTV IYRWNDIGNI AHNKSSIVLE LVNKEENVLF HTDDLENAKY VSRLFAARHK
FYKQNKICTE QSNSPPPIRR RPTWSRSSLP RQHPFILPPM HVQCGEHYTE THNSQDSIFH
GNEETFYCRS QTSLDRCPMD FSYLNGNGPN GSVCSAHSMN SLNRSQNFIQ ASPMSSNLSI
PGSDIMRADY IPSHRHSAII VPSYRPTPDY ETVMRQMKRG VIQMDSQSQS LRNLNIGNTH
AYKQAEDLVY SQPEIRERHP YTITYGPQGG SYNKPVAPSD QMNPNNAVQN KTAASAISHT
VSTPELANMQ LQSSQSYNTT HMLKNYLFRP PPPYPRPRPA TSTPDLASHR HKYVSGSSPD
LVTRKVQLSV KTFQEDSSPV VRQSLQEVSE PLMAVKHHAA VNKRHSLEVI SNMVRGIEAM
ALKTLNAPLP RRNTLREQVQ PEESVQMGHE VQHVPHYHHK KTFSNATMLI HSSESEEEEE
TSESVSQITA LHENMEYSAQ LQAALARIPN KPPPEYPGPR KSVSNGALRQ DPVSISVAVA
RAKAMRPGPS KAISVSRTDQ MAINGSSLGP SISEPDLTSV KERVKKEPVK ERPVSEMFSI
EDSIIEREIM MRNLEKQKMA GLEAQKRPLM LAALNGLSVA RVPVPEDSQD EVAKVPMDER
CKILKRKLEE GMVFTEYEQI PKKKADGIFT TAALPENTER NRIREVIPYE ENRVELVPTK
ENNTGYINAS HIKVTVGGEE WHYIATQGPL PHTCHDFWQM VWEQGVNVIA MVTAEEEGGR
SKSHRYWPKL GSKHSSATYG KFKVTTKFRT DSGCYATTGL KVKHLLSGQE RTVWHLQYTD
WPDHGCPEEV QGFLSYLEEI QSVRRHTNSV LDSSNNCNPP IVVHCSAGVG RTGVVILTEL
MIGCLEHNEK VDVPVMLRHL REQRMFMIQT IAQYKFVYQV LIQFLQNSRL I
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