ID   A0A091G9K4_9AVES        Unreviewed;       946 AA.
AC   A0A091G9K4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   03-MAY-2023, entry version 29.
DE   SubName: Full=Sorting nexin-14 {ECO:0000313|EMBL:KFO79055.1};
GN   ORFNames=N303_02346 {ECO:0000313|EMBL:KFO79055.1};
OS   Cuculus canorus (common cuckoo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX   NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO79055.1, ECO:0000313|Proteomes:UP000053760};
RN   [1] {ECO:0000313|EMBL:KFO79055.1, ECO:0000313|Proteomes:UP000053760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO79055.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KL447974; KFO79055.1; -; Genomic_DNA.
DR   RefSeq; XP_009563081.1; XM_009564786.1.
DR   AlphaFoldDB; A0A091G9K4; -.
DR   STRING; 55661.A0A091G9K4; -.
DR   GeneID; 104062689; -.
DR   KEGG; cuca:104062689; -.
DR   CTD; 57231; -.
DR   OrthoDB; 2877434at2759; -.
DR   Proteomes; UP000053760; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        52..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          130..304
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          336..468
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          570..690
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   946 AA;  109696 MW;  F2DA53AE845F2A60 CRC64;
     MGGARAAARR LRQRVRGAGA VREVCRQYPL SCCLLLGLGA ATLLLNRYLH VLMIFWSFVA
     GVITFYCSLG PDSLLPSILF TIKYKPKQLE LPELFPHGHS CAVCGKVKCK RHRPTLLLEN
     YQPWLDLKVP SKVDASLSEV LELVLENFIY PWYRNITDDE SSVDELRGTL RFFASVLVRR
     IHKVDIPTVV TKKMLKAAMK HIEVIAKARQ KVKNAEFLQQ AALEEYGPEL HVALRSRRDE
     LHYLRKLTEL LFPYILPPKS TECRSLALLI REILPGSVFL PSMDFLADPD TVNHLLLIFI
     DDSPPEKATE PTSSLVPFLQ KFAEPRNKKP SVLKLELKEI RDQQDLLFRF MNFLKQEGAV
     HVLQFCLTVE EFNDRILRPE LSDTEKMSLH EEVQKIYKTY CLDESIDKIR FDPFIVEEIQ
     RIAEGPYMDV VKLQTMRCLF EAYEHVLSLL ENVFTPMFCH SDEYFRHLLR GAESPTRNSK
     FNRSSLSLDD FRTTQKRGES FGISRIGNKI KGVFKSSAME GAMLPNYNLN EGEDDFIEEG
     VMVMEDDSPE EAVSTPNTPR NLAAWKISIP YVDFFDDPSL ERKDRKERIP VFCIDVERND
     RRAVGHEPEH WSVYRRYLEF YVLESKLTEF HGTFPDAQLP SKRIIGPKNY EFLKSKREEF
     QEYLQKLLQH PELSNSQLLA DFLSPNGGET QFLDKMLPDV NLGKIIKSVP GKLMKEKGQH
     LEPFIMNFIN SCESPKPKPC RPELTILSPT SENNKKLFND LFKNNANRSE NTERRQNQNY
     FMEVMTVEGV YDYLMYVGRV VFRIPDWLHH LLMGGRILFK NTLELYTDYY LHCKLEQLFQ
     EHRLVSLITL LRDAVFCENT EPRSLQDKQK RAKQTFEEMM RYIPDLIGKC IGEEAKYEGI
     RLLFDGMQQP VLNKQLTYVL LDIGIQELFP ELSKGPKEVS SASGWM
//