ID A0A091GEC5_9AVES Unreviewed; 446 AA.
AC A0A091GEC5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=[histone H3]-lysine(4) N-trimethyltransferase {ECO:0000256|ARBA:ARBA00012182};
DE EC=2.1.1.354 {ECO:0000256|ARBA:ARBA00012182};
DE Flags: Fragment;
GN ORFNames=N303_09565 {ECO:0000313|EMBL:KFO72522.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO72522.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO72522.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO72522.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) +
CC N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60260, Rhea:RHEA-COMP:15537, Rhea:RHEA-
CC COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.354;
CC Evidence={ECO:0000256|ARBA:ARBA00000944};
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DR EMBL; KL447350; KFO72522.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091GEC5; -.
DR STRING; 55661.A0A091GEC5; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0042800; F:histone H3K4 methyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10526; SET_SMYD1; 1.
DR Gene3D; 1.10.220.160; -; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044418; SMYD1_SET.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR12197; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD; 1.
DR PANTHER; PTHR12197:SF184; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD1; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:KFO72522.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Transferase {ECO:0000313|EMBL:KFO72522.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 7..45
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT DOMAIN 57..208
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO72522.1"
FT NON_TER 446
FT /evidence="ECO:0000313|EMBL:KFO72522.1"
SQ SEQUENCE 446 AA; 51254 MW; 40E75EFC2C29C7B8 CRC64;
SLTHVICHTC FKRQDRLHRC GQCKFAYYCD RTCQRAAWLN HKNECAAIKK YGKAPTENIR
LAARIMWKIE REGSGLAEGC LVSIDDLQNH VDSFGEEEKK ELRTDVESFL EFWPPQSQQF
GLQFISHIFG VISCNGFTLS DQRGLQAVGV GVFPNLCQVN HDCWPNCTVI FNNGNHEAVR
SMFHTQMRIE LRALSKISPG DELTVSYVDF LNVSEERRKQ LKKQYYFDCT CEHCKKQIKD
DLMLAVKEGE GKPSAETVKE VIQFSKDTLE KINKARMEGL YHEVVKLCRE CLKKQEPVLG
DTNIYLLRIL SIASEVLSYL QMFEEAADYA KRMVDGYLKI YHPNNAQLGM AVMRAGVTHW
HAGLIEAGHG LICKAYAILL ITHGPSHPIT KDLEVMRVQT EMELRMFQQN EYMYYKMREA
ALKNQKIQVM PEPSNEAPPG LFHKKE
//
