ID A0A091GEX1_9AVES Unreviewed; 667 AA.
AC A0A091GEX1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=N303_05701 {ECO:0000313|EMBL:KFO80528.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO80528.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO80528.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO80528.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL448112; KFO80528.1; -; Genomic_DNA.
DR RefSeq; XP_009565059.1; XM_009566764.1.
DR AlphaFoldDB; A0A091GEX1; -.
DR STRING; 55661.A0A091GEX1; -.
DR GeneID; 104064430; -.
DR KEGG; cuca:104064430; -.
DR CTD; 56924; -.
DR OrthoDB; 460351at2759; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06659; STKc_PAK6; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR035066; STKc_PAK6.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF19; SERINE_THREONINE-PROTEIN KINASE PAK 6; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:KFO80528.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Transferase {ECO:0000313|EMBL:KFO80528.1}.
FT DOMAIN 12..25
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 393..644
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 422
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 667 AA; 74863 MW; DBDBAED32D9CE7EE CRC64;
MFRKKKKKRP EISAPQNFEH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP KPVVDPSRIT
RMQLQPMKTV VRGSTVEVEG YISGILNDIQ KLSAISSNTL RGRSPTSRRR AQSLGLLGED
RPPDMYLQSP EADWVDKYGN YLNCNGGTKV TRRQTMWPDY KPRLEGQSHS NGMVMKAQSL
GPSEFQDADD SCLQRASGLQ HMPTLPGENE KTGRKSSEEC WPQPCLLRQA NSRPSGEGSP
SSKSRENSLK RRLLRSVFPS SSGSNKSGPS LQIKPNTLFR PQQWGSPRSP GAKAQSLPPD
QPSSDFPKII SEAGTPQKSP TVEKAMAVPQ GRPSPAGSPR NRQTQTSSSN LHLPQDSSVK
GQLASEDPVV VTHEQFKAAL RMVVDQGDPR SLLENYVKIG EGSTGIVCIA REKHSGRQVA
VKMMDLRKQQ RRELLFNEVV IMRDYQHVNV VEMYKSYLVG DELWVLMEFL QGGALTDIVS
QIRLNEEQIA TVCESVLQAL SYLHSQGVIH RDIKSDSILL TLDGRVKLSD FGFCAQISKD
VPKRKSLVGT PYWMAPEVIA RIPYATEVDI WSLGIMVIEM VDGEPPYFSD SPVQAMKRLR
DSPPPKLKNF HRTSPVLRDF LERMLTRDPL ERATAQELLD HPFLLQTGLP ECLVPLIQQY
RKRTSTC
//
