ID A0A091GGQ7_9AVES Unreviewed; 627 AA.
AC A0A091GGQ7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=High affinity cationic amino acid transporter 1 {ECO:0000313|EMBL:KFO80334.1};
GN ORFNames=N303_02115 {ECO:0000313|EMBL:KFO80334.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO80334.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO80334.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO80334.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143,
CC ChEBI:CHEBI:32682; Evidence={ECO:0000256|ARBA:ARBA00034423};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine(in) = L-lysine(out); Xref=Rhea:RHEA:70935,
CC ChEBI:CHEBI:32551; Evidence={ECO:0000256|ARBA:ARBA00034422};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ornithine(in) = L-ornithine(out); Xref=Rhea:RHEA:71199,
CC ChEBI:CHEBI:46911; Evidence={ECO:0000256|ARBA:ARBA00034450};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC {ECO:0000256|ARBA:ARBA00008572}.
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DR EMBL; KL448103; KFO80334.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091GGQ7; -.
DR STRING; 55661.A0A091GGQ7; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004755; Cat_AA_permease.
DR InterPro; IPR029485; CAT_C.
DR NCBIfam; TIGR00906; 2A0303; 1.
DR PANTHER; PTHR43243:SF28; HIGH AFFINITY CATIONIC AMINO ACID TRANSPORTER 1; 1.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
DR PIRSF; PIRSF006060; AA_transporter; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 554..604
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
SQ SEQUENCE 627 AA; 68218 MW; A8D1F3E1B369E24E CRC64;
MECQKIINFG NQLIRRKNVD CTREDSRLSR CLNTFDLVAL GVGSTLGAGV YVLAGAVARE
NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS
YVIGTSSVAR AWSATFDEII GQHIEKFCKK YMTMEAPGVL AKYPDIFAVV IIVILTGLLI
VGVKESALVN KVFTCINILV LGFVMVSGFV KGSVKNWQLT EQDIYNISIY GVNAMPFSQT
QEEKLYGVGG FMPYGWKGVL SGAATCFYAF VGFDCIATTG EEVKNPQKAI PIGIVASLLI
CFVAYFGVSA ALTLMMPYYK LDTNSPLPNA FKYVDWDGAN YAVAVGSLCA LSTSLLGSMF
PMPRIIYAMA EDGLLFKFLA RVNEKRKTPI IATVSSGAVA ALMAFLFDLK DLVDLMSIGT
LLAYSLVAAC VLVLRYQPEQ PNLAYQMART TEETDNNESV STSESQAGFL PEEEEKCSLK
AILCPPNSDP SKFSGSVVNV SAFIIGFLIV GSCILTALEP SVLIKTVWII AAILVLVVSF
IIWKQPESKT KLSFKVPLLP LLPVLSIFVN VYLMMQLDIG TWIRFAIWML LGFIIYFSYG
IWHSVEATYA ASADAERNID AGLDSCK
//
