ID A0A091GHH0_9AVES Unreviewed; 513 AA.
AC A0A091GHH0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Signal transducing adapter molecule 2 {ECO:0000313|EMBL:KFO73602.1};
DE Flags: Fragment;
GN ORFNames=N303_11398 {ECO:0000313|EMBL:KFO73602.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO73602.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO73602.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO73602.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}.
CC -!- SIMILARITY: Belongs to the STAM family.
CC {ECO:0000256|ARBA:ARBA00009666}.
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DR EMBL; KL447456; KFO73602.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091GHH0; -.
DR STRING; 55661.A0A091GHH0; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd21390; GAT_STAM2; 1.
DR CDD; cd11963; SH3_STAM2; 1.
DR CDD; cd16999; VHS_STAM2; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035675; STAM2_SH3.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002014; VHS_dom.
DR InterPro; IPR047493; VHS_STAM2.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF1; SIGNAL TRANSDUCING ADAPTER MOLECULE 2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF02809; UIM; 1.
DR Pfam; PF00790; VHS; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00726; UIM; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 4..131
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 189..248
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT COILED 320..354
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO73602.1"
FT NON_TER 513
FT /evidence="ECO:0000313|EMBL:KFO73602.1"
SQ SEQUENCE 513 AA; 56164 MW; D9BF99ED7921852F CRC64;
IEKATNEYNT SEDWGLIMDI CDKVGSTPNG AKDCLKAIMK RVNHKVPHVA LQALTLLGAC
VSNCGKIFHL EVCSRDFATE ARGIINKAHP KVCEKLKALM VEWSEEFQKD PQCSLISATI
KSLKEEGVTF PAAGSQATTN AAKNGSSLSK NKEDEDIAKA IELSLQEQKQ QQMETRSLYP
AAEIQQNNQN SRKVRALYDF EAVEDNELTF KSGEIIFVLD DSDANWWKGE NHRGVGLFPS
NFVTSDLTVE PEAATVDKNS VPEETPEEIK KAEPEPVYID EDKMDKTLQV LQSIDPTDLK
LDSPDLLDSE GICQQMGPMI DEKLEEIDRK HSELSELNVK VLEALELYNK LMNEAPMYSA
YSKLHHPAQY PPTSSGVSVQ SFPVQPPSGS YLIQGVHPVT MSPGYSLGHD QLGQLRSLPQ
SINSSGATQP AQAAYLSPAP DAVLNQTYVS QSASLPSAAG TTAYSQQQLG MAVDMSAYQN
NASSLPQGPG YPVAVPAHSV LQQQTNYHQQ PLL
//
