ID A0A091GN64_9AVES Unreviewed; 698 AA.
AC A0A091GN64;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 40.
DE SubName: Full=Calpain-8 {ECO:0000313|EMBL:KFO82639.1};
GN ORFNames=N303_13799 {ECO:0000313|EMBL:KFO82639.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO82639.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO82639.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO82639.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; KL448315; KFO82639.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091GN64; -.
DR STRING; 55661.A0A091GN64; -.
DR MEROPS; C02.007; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR CDD; cd16191; EFh_PEF_CAPN8; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF374; CALPAIN-8; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 45..344
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 600..635
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT ACT_SITE 105
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 262
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 286
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 698 AA; 79223 MW; 64CCBD4BAEF5B2DE CRC64;
MSGAAVRLCQ ERATMDGLGS KRNAIKYLKQ DYEALKQQCL QSGTLFKDEE FPACPSALGY
RDLGPYSFKT QGIIWKRPTE LCANPQFIVG GATRTDVCQG ELGDCWLLAA IASLTLNPDV
LYRVVPKAQS FQEDYAGIFH FQFWQYGEWV DVVVDDRLPT KNGKLLFVHS EESNEFWSAL
LEKAYAKLNG SYEALTGGST IEGFEDFTGG ISESYELRKA PSNLYQIIRK ALRAGSLLGC
SIDITTAADV EAITSLKLVK GHAYSVTGAE EVYYRGQPEK LVRLRNPWGE VEWTGAWSDN
APEWNFVDPK QKHALDKQVD DGEFWMAFSD FQRQFTRLEI CNLTPDTLTS NKVNKWDLTL
FNGQWRRGST AGGCQNYQAT YWTNPQFKIR LDEPDDDHEG SLNEPCCTIL VGLMQKNRRR
QKKMGEALLS IGYSLYQLEN ITDIHVNRAF FARNQSVARS DPYVNLREVS SRMKLPRGEY
LIVPSTFEPY KNGEFCLRVF SEKKAKMQII GDVIAANPYE PHVSNKDIDD EFKTLFEKLS
GEDCEVTANE LQTILNRVLS KRKDVKSDGF NINTCREMIS LLDINGTGTL GLIEFKILWM
KIQKYLAIYK KVDSDYSGTI DSHEMRNALR EAGFTLNNQV QHSIVIRYAC SKLTIDFDGF
VACMIHLETL FKVFHLLDKD KSGIIQLSLA EWLCCTLV
//