ID A0A091GNJ3_9AVES Unreviewed; 656 AA.
AC A0A091GNJ3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
DE Flags: Fragment;
GN ORFNames=N303_08130 {ECO:0000313|EMBL:KFO82856.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO82856.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO82856.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO82856.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KL448321; KFO82856.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091GNJ3; -.
DR STRING; 55661.A0A091GNJ3; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 5.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044:SF320; DELTA-LIKE PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 503..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 142..186
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 253..291
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 293..329
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 331..369
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 371..407
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 409..445
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 448..486
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 144..153
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 157..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 177..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 281..290
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 319..328
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 340..357
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 359..368
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 397..406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 435..444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 457..474
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 476..485
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO82856.1"
FT NON_TER 656
FT /evidence="ECO:0000313|EMBL:KFO82856.1"
SQ SEQUENCE 656 AA; 72822 MW; 7CCA38B4C7C5DC13 CRC64;
RVSGSGVFQL ELHEFVNSHG SLASGKPCSP HCRTFFRICL KHFQAVVSPG SCTFGSIITP
VLGINTFSIK DTERFDSPIK LPFNFTWPVR FCRELDGGGS RPPSEDWLIS QMSIQRSLSV
GEDWSQDVQS GPLTQLRYSY RVVCSENYYG ESCSRLCKRR DDRFGHYVCE PDGSLACLPG
WTGEYCTEPI CLSGCTEQNG YCNKPGECIC RPGWQGRYCD ECIPHIGCRH GTCKTQWQCI
CDEGWGGLFC DQDLNYCTHH RPCKNGATCM NTGQGSYTCS CKPGFTGVDC EHEISECDSN
PCRNGGSCTD MENGYHCLCP PGYYGTHCEH SALTCIDSPC FNGGTCLEKE QGASYTCICP
FGFTGSNCEK KVDRCTSNPC ANDGNCFYLG QIRVCRCRAG FSGQKCEINI NDCARNPCSN
GGTCHDLIND YTCTCLPGYS GRNCDIKTRD ECASGPCENG GTCYSGLYSA SFVCYCPPDF
MGNRCELPVH TVSVTLPPKP VPWIAISMGV GLVALLILFC MIAMVIRQMR MHPEQDSETM
NNLSDFQKDN LIPASQLKNT NKNKDLEVDC GLEKSNYKPK NHKLDYNLVK DLTSRGTQED
KYYKSEKCLG EKSPLRLHSE KPECRISAIC SPRDSMYQSV FVITEERNEC IIATEV
//
