ID A0A091GQQ5_9AVES Unreviewed; 661 AA.
AC A0A091GQQ5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Leucine-rich repeat transmembrane protein FLRT2 {ECO:0000313|EMBL:KFO76452.1};
GN ORFNames=N303_08043 {ECO:0000313|EMBL:KFO76452.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO76452.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO76452.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO76452.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004162}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004586}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; KL447706; KFO76452.1; -; Genomic_DNA.
DR RefSeq; XP_009559603.1; XM_009561308.1.
DR AlphaFoldDB; A0A091GQQ5; -.
DR STRING; 55661.A0A091GQQ5; -.
DR KEGG; cuca:104059617; -.
DR OrthoDB; 2916435at2759; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF16; LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT2; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01463; LRRCT; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:KFO76452.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..661
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001875541"
FT TRANSMEM 542..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 420..518
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 661 AA; 74359 MW; FAC1215BEDAA24F7 CRC64;
MGSWTRMRPT DWAVLMKSWL IFSLGLYMQV SKTSACPKVC RCDRNFVYCN ERSLTSVPLG
IPEGVTVLYL HNNQINNAGF PAELHNVQSV HTVYLYGNQL DEFPMNLPKN VRVLHLQENN
IQTISRAALA QLLKLEELHL DDNSISTVGV EDGAFREAIS LKLLFLSKNH LSSVPVGLPV
DLQELRVDEN RIAVISDLAF QNLTSLERLI VDGNLLTNKG IAEGTFSHLS KLKEFSIVRN
SLTYPPPDLP GTHLLRLYLQ DNQITHIPLT AFSNLHKLER LDISNNQLRM LVKGVFDNLH
NLRQLTVRNN PWLCDCSIKW VTEWLKFIPT SINVRGFMCQ GPEQVRGMAV RELNMNMLSC
PTTTPGVPFI ITPVAATAMP TTLVSTSSVA PPSSKYNPLT PTIATLPTVP EREDRERVTP
PLSERIQLSI HFVNDTCIQV NWMSSFNVMA YKLTWVKMGH SLVGGIVQEQ VVSGEKQHLS
LVNLEPKSTY RICLVPLDTY NYRTGEDTVC SEATTKASFL SNGSNIPSSH EQTTSQNLGS
PFLLAGLIGG AVIFVLVVLL SIFCWHMHKK GRYTSQKWKY NRGRRKDDYC EAGTKKDNSI
LEMTETSFQI VSLNNDQLLK GDFRLQPIYT PNGGINYTDC HIPNNMRYCN SNVSDLEHCH
T
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