ID A0A091GU89_9AVES Unreviewed; 170 AA.
AC A0A091GU89;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 20.
DE SubName: Full=AP-3 complex subunit sigma-1 {ECO:0000313|EMBL:KFO77682.1};
DE Flags: Fragment;
GN ORFNames=N303_04812 {ECO:0000313|EMBL:KFO77682.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO77682.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO77682.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO77682.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC not clathrin-associated. The complex is associated with the Golgi
CC region as well as more peripheral structures. It facilitates the
CC budding of vesicles from the Golgi membrane and may be directly
CC involved in trafficking to lysosomes. In concert with the BLOC-1
CC complex, AP-3 is required to target cargos into vesicles assembled at
CC cell bodies for delivery into neurites and nerve terminals.
CC {ECO:0000256|ARBA:ARBA00025605}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC {ECO:0000256|ARBA:ARBA00006972}.
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DR EMBL; KL447831; KFO77682.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091GU89; -.
DR STRING; 55661.A0A091GU89; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0030123; C:AP-3 adaptor complex; IEA:InterPro.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006896; P:Golgi to vacuole transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd14834; AP3_sigma; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR InterPro; IPR016635; AP_complex_ssu.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR027155; APS3.
DR InterPro; IPR000804; Clathrin_sm-chain_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR11753; ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY; 1.
DR PANTHER; PTHR11753:SF12; AP-3 COMPLEX SUBUNIT SIGMA-1; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 2..124
FT /note="AP complex mu/sigma subunit"
FT /evidence="ECO:0000259|Pfam:PF01217"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO77682.1"
FT NON_TER 170
FT /evidence="ECO:0000313|EMBL:KFO77682.1"
SQ SEQUENCE 170 AA; 18971 MW; 451B3D70DA825056 CRC64;
SEDTQQQIIR ETFHLVSKRD ENVCNFLEGG LLIGGSDNKL IYRHYATLYF VFCVDSSESE
LGILDLIQVF VETLDKCFEN VCELDLIFHV DKVHNILAEM VMGGMVLETN MNEIVTQIDA
QNKLEKSEAG LAGAPARAVS AVKNMNLPEI PRNINIGDIS IKVPNLPSFK
//
