ID A0A091GZV7_BUCRH Unreviewed; 1049 AA.
AC A0A091GZV7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Solute carrier family 12 member 4 {ECO:0000313|EMBL:KFO87945.1};
DE Flags: Fragment;
GN ORFNames=N320_11366 {ECO:0000313|EMBL:KFO87945.1};
OS Buceros rhinoceros silvestris.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO87945.1, ECO:0000313|Proteomes:UP000054064};
RN [1] {ECO:0000313|EMBL:KFO87945.1, ECO:0000313|Proteomes:UP000054064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO87945.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; KL515756; KFO87945.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091GZV7; -.
DR Proteomes; UP000054064; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF46; SOLUTE CARRIER FAMILY 12 MEMBER 4; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000054064};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 88..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 88..263
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 369..659
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 673..790
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 803..1049
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO87945.1"
FT NON_TER 1049
FT /evidence="ECO:0000313|EMBL:KFO87945.1"
SQ SEQUENCE 1049 AA; 116596 MW; 4F3C3A07571C0B1C CRC64;
SAGHGNHKEN SPFLNSTEAG KGGDYYDRNL ALFEEELDIR PKVSSLLGKL VNYTNLTQGV
KEHEEAESTD GSKKKVSKSP SMGTLMGVYL PCMQNIFGVI LFLRLTWMVG MAGVLQSFLI
VLLCCCCTML TTISMSAIAT NGVVPAGGSY FMISRSLGPE FGGAVGLCFY LGTTFAGAMY
ILGAIEILLT YIVPQAAIFH PSGAHDASST MLNNMRVYGT VFLILMAVVV FVGVKYVNKF
ASLFLACVVI SILSIYAGAI KSIFDPPEFP ICMLGNRTLS RDQFDVCAKT IVKDNITVAS
KLWELFCHTT NLTTENCDEY FLMNNVSQIA GIPGAASGIL KDNLWSNYLE KGEILEKAHH
PSVDVAGQKN NLHLYVLSDI ATSFMVLVGI FFPSVTGIMA GSNRSGDLKD AQKSIPVGTI
LAIVTTSLVY LSCVLLFGAC IEGVVLRDKY GDAVNKNLVV GTLSWPSPWV IVIGSFFSTC
GAGLQSLTGA PRLLQAIAKD NIIPFLWVFG HGKANGEPTW ALLLTALIAE LGILIASLDM
VAPILSMFFL MCYLFVNLAC AVQTLLRTPN WRPRFKYYHW ALSFLGMSIC LALMFISSWY
YALVAMLIAG MIYKYIEYQG AEKEWGDGIR GLSLSAARYA LLRLEEGPPH TKNWRPQLLV
LLKLDEDLHV KYPRLLTFAS QLKAGKGLTI IGSVIQGNFL ETYGEAQAAE QTIKNMMDIE
KVKGFCQVVV ANKVREGIAH LIQSCGLGGM KHNTVVLGWP YGWRQSEDPR SWKTFIGTVR
CTTAAHLALL VPKNVAFYPS NHERYNEGNI DVWWIVHDGG MLMLLPFLLK QHKVWRKCKM
RIFTVAQMDD NSIQMKKDLA TFLYQLRIEA EVEVVEMHNS DISAYTYERT LMMEQRSQML
RQMRLTKTER EREAQLVKDR HSIARLESLY SDEEDEGDSV PENIQMTWTK EKCDAEKRNR
GSAVGSFRDL ISIKPNQSNV RRMHTAVKLN EVIVNRSHDA RLVLLNMPGP PKNTDGDENY
MEFLEVLTEG LERVLLVRGG GREVITIYS
//
