ID A0A091H1D7_9AVES Unreviewed; 507 AA.
AC A0A091H1D7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Rho guanine nucleotide exchange factor 9 {ECO:0000256|ARBA:ARBA00017486};
DE AltName: Full=Collybistin {ECO:0000256|ARBA:ARBA00031572};
DE AltName: Full=Rac/Cdc42 guanine nucleotide exchange factor 9 {ECO:0000256|ARBA:ARBA00032237};
DE Flags: Fragment;
GN ORFNames=N303_11839 {ECO:0000313|EMBL:KFO80142.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO80142.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO80142.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO80142.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for CDC42.
CC Promotes formation of GPHN clusters. {ECO:0000256|ARBA:ARBA00043844}.
CC -!- SUBUNIT: Interacts with GPHN. {ECO:0000256|ARBA:ARBA00011232}.
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DR EMBL; KL448088; KFO80142.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091H1D7; -.
DR STRING; 55661.A0A091H1D7; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11975; SH3_ARHGEF9; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035728; ARHGEF9_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 6..65
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 101..285
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 316..423
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 455..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO80142.1"
FT NON_TER 507
FT /evidence="ECO:0000313|EMBL:KFO80142.1"
SQ SEQUENCE 507 AA; 59758 MW; 73F6958EFB0FC8D2 CRC64;
KLISGGSIVS AEAVWDHVTM ANRELAFKAG DVIKVLDASN KDWWWGQIDD EEGWFPASFV
RLWVNQEDGV EEGTSDVQNG HLDPSADCLC LGRTVQNRDQ MRANVINEIM STERHYIKHL
KDICEGYLKQ CRKRRDMFSD EQLKIIFGNI EDIYRFQMGF VRDLEKQYNN EDPHLSEIGP
CFLEHQDGFW IYSEYCNNHL DACMELSKLM KDSRYQHFFE ACRLLQQMID IAIDGFLLTP
VQKICKYPLQ LAELLKYTAQ DHSDYRYVAA ALAVMRNVTL QINERKRRLE NIDKIAQWQA
SVLDWEGDDI LDRSSELIYT GEMSWIYQPY GRNQQRVFFL FDHQMVLCKK DLIRRDILYY
KGRIDMDKYE VVDIEDGRDD DFNVSMKNAF KLHNKETEEM HLFFAKKLEE KLRWLRAFRE
ERKMVKEDEK IGFEISENQK RQAAMTVKKV SKQKGVSYSK SVPPAYPPPQ DPLNQGQYMV
TDGISQSQVF EFTEPRRSQA PFWQNFS
//
