GenomeNet

Database: UniProt
Entry: A0A091H1L7_BUCRH
LinkDB: A0A091H1L7_BUCRH
Original site: A0A091H1L7_BUCRH 
ID   A0A091H1L7_BUCRH        Unreviewed;      1636 AA.
AC   A0A091H1L7;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=[histone H3]-trimethyl-L-lysine(4) demethylase {ECO:0000256|ARBA:ARBA00012902};
DE            EC=1.14.11.67 {ECO:0000256|ARBA:ARBA00012902};
DE   Flags: Fragment;
GN   ORFNames=N320_00641 {ECO:0000313|EMBL:KFO88525.1};
OS   Buceros rhinoceros silvestris.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX   NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO88525.1, ECO:0000313|Proteomes:UP000054064};
RN   [1] {ECO:0000313|EMBL:KFO88525.1, ECO:0000313|Proteomes:UP000054064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO88525.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-
CC         [histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone
CC         H3] + 3 succinate; Xref=Rhea:RHEA:60208, Rhea:RHEA-COMP:15537,
CC         Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:30031, ChEBI:CHEBI:61961; EC=1.14.11.67;
CC         Evidence={ECO:0000256|ARBA:ARBA00000604};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954};
CC   -!- SIMILARITY: Belongs to the JARID1 histone demethylase family.
CC       {ECO:0000256|ARBA:ARBA00006801}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KL517532; KFO88525.1; -; Genomic_DNA.
DR   Proteomes; UP000054064; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0034647; F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd16873; ARID_KDM5A; 1.
DR   CDD; cd15602; PHD1_KDM5A; 1.
DR   CDD; cd15606; PHD2_KDM5A; 1.
DR   CDD; cd15686; PHD3_KDM5A; 1.
DR   Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR   Gene3D; 2.60.120.650; Cupin; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR   InterPro; IPR001606; ARID_dom.
DR   InterPro; IPR036431; ARID_dom_sf.
DR   InterPro; IPR003347; JmjC_dom.
DR   InterPro; IPR048615; KDM5_C-hel.
DR   InterPro; IPR047974; KDM5A_ARID.
DR   InterPro; IPR047973; KDM5A_PHD1.
DR   InterPro; IPR047970; KDM5A_PHD2.
DR   InterPro; IPR047972; KDM5A_PHD3.
DR   InterPro; IPR013637; Lys_sp_deMease-like_dom.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR004198; Znf_C5HC2.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR   PANTHER; PTHR10694:SF17; LYSINE-SPECIFIC DEMETHYLASE 5A; 1.
DR   Pfam; PF01388; ARID; 1.
DR   Pfam; PF02373; JmjC; 1.
DR   Pfam; PF21323; KDM5_C-hel; 1.
DR   Pfam; PF00628; PHD; 2.
DR   Pfam; PF08429; PLU-1; 1.
DR   Pfam; PF02928; zf-C5HC2; 1.
DR   SMART; SM01014; ARID; 1.
DR   SMART; SM00501; BRIGHT; 1.
DR   SMART; SM00558; JmjC; 1.
DR   SMART; SM00249; PHD; 3.
DR   SUPFAM; SSF46774; ARID-like; 1.
DR   SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR   PROSITE; PS51011; ARID; 1.
DR   PROSITE; PS51184; JMJC; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 2.
DR   PROSITE; PS50016; ZF_PHD_2; 3.
PE   3: Inferred from homology;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methyltransferase {ECO:0000313|EMBL:KFO88525.1};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054064};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000313|EMBL:KFO88525.1};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00146}.
FT   DOMAIN          29..119
FT                   /note="ARID"
FT                   /evidence="ECO:0000259|PROSITE:PS51011"
FT   DOMAIN          237..287
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   DOMAIN          381..547
FT                   /note="JmjC"
FT                   /evidence="ECO:0000259|PROSITE:PS51184"
FT   DOMAIN          1105..1162
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   DOMAIN          1551..1605
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   REGION          1271..1292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1351..1375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1436..1458
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1485..1520
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFO88525.1"
FT   NON_TER         1636
FT                   /evidence="ECO:0000313|EMBL:KFO88525.1"
SQ   SEQUENCE   1636 AA;  186430 MW;  F05845C811202F17 CRC64;
     DWQPPFACEV QSFRFTPRIQ RLNELEAMTR VKLDFLDQLA KFWELQGSNL KIPVVERKIL
     DLYGLSKIVA SKGGFEVVTK EKKWSKVASR LGYLPGKGTG SLLKSHYERI LYPYELFQSG
     VSLMGIQKSN LDLKEKVEAE DHSLDAQTSP KQASRMNVVL KRTRRVKSQA EAGEMSRNTE
     LKKLQIFGAG PKMMGLALGT KDKEDEVTRR RKGTRSEAFG MQMRQRKGTL SVNFVDLYVC
     LFCGRGNNED KLLLCDGCDD SYHTFCLIPP LPDVPKGDWR CPKCVAEECN KPREAFGFEQ
     AVREYTLQSF GEMADNFKSD YFNMPVHMVP TELVEKEFWR LVSSIEEDVI VEYGADISSK
     DFGSGFPVKD GRRKLMPEEE DYALSGWNLN NMPILEQSVL AHINADISGM KVPWLYVGMC
     FSSFCWHIED HWSYSINYLH WGEPKTWYGV PSHAAEQLED VMKELAPELF ESQPDLLHQL
     VTIMNPNVLM EHGVPVYRTN QCAGEFVVTF PRAYHSGFNQ GYNFAEAVNF CTADWLPIGR
     QCVSHYRRLG RHCVFSHEEL IFKMAADPEC LDVGLAAMVC KEMTLMIEEE TRLRDSVVQM
     GVLMSEEEVF ELVPDDERQC TACRTTCFLS ALTCSCNPER LVCLYHPSDL CPCPMQKKCL
     RYRYPLEDLP SLLYGVKVRA QSYDTWVSRV TEALSANLNH KKDVIELRVM LEDAEDRKYP
     ENDLFRRLRD AVKEAETCAS VAQLLLSKKQ KHRQSQESGR TRTKLTMEEL KAFVQQLFSL
     PCVISQARQV KNLLDDVEEF HERAQEAMMD EIPDSSKLQE LIDMGSGLYV ELPELPRLKQ
     ELQQARWLDE VRSTLLDPQR VTLDVMKKLI DSGVGLAPHH AVEKAMAELQ ELLTVSERWE
     EKAKVCLQAR PRQSMMALEG IVNEAKNIPA YLPNVLALKE ALQRARDWTA KVEAIQNGSN
     YAYLEQLENL TAKGRPIPVR LDALPQLESQ VAAARAWRER TGRTFLKKNS SYSLLQVLSP
     RTDIGVYGSS KNRRKRVKEL MEKEKEKELD LESLSELEDG LEEARDTAAV VAIFKEREQK
     EIEAMHALRA ANLAKMTMVD RIEEVKFCIC RKTAIGFMLQ CELCKDWFHS GCVPLPKTSS
     QKKGSSWQAK EVKFLCPLCM RSRRPRLETI LSLLVSLQKL PVRLPEGEAL QCLTERAMSW
     QDRARQALAT DELSSALAKL SVLSQRMVEQ AAREKTEKII SAELQKAAAN PDLQGHLTNF
     QQSAFNRVIG SVSSSPRQTL DYDDEETDSD EDIRETYGYD IKDNASVKSS SSLEPNLFCD
     EEIPIKSEEV VTHMWTAPSF CAEHAYSSAS KSCSQGSSTP RKQPRKSPLV PRSLEPPVLE
     LSAGAKAQLE DLMMVGDLLE VSLDETQHIW RILQATHPPS EDRFLHVMED DSMDEKPLKM
     RGRDSSERKR KRKLERAEQF FGDMKQKSKE LKKLEKPKKK KLKLSIDKTK ELNKLAKKLA
     KEEERKKKRE KAVVAKVELA KESTEKKREK KVLDIPSKYD WSGAEDSDDE NAVCAAQNCQ
     RPCKDKVDWV QCDGGCDEWF HQVCVGVSPE MAENEDYICI NCAKKPVQGP SSPAHAPPPP
     FILSYKLPME DLKETS
//
DBGET integrated database retrieval system