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Database: UniProt
Entry: A0A091H2A3_BUCRH
LinkDB: A0A091H2A3_BUCRH
Original site: A0A091H2A3_BUCRH 
ID   A0A091H2A3_BUCRH        Unreviewed;      2019 AA.
AC   A0A091H2A3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   28-FEB-2018, entry version 24.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=N320_00381 {ECO:0000313|EMBL:KFO89539.1};
OS   Buceros rhinoceros silvestris.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX   NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO89539.1, ECO:0000313|Proteomes:UP000054064};
RN   [1] {ECO:0000313|EMBL:KFO89539.1, ECO:0000313|Proteomes:UP000054064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO89539.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KL520759; KFO89539.1; -; Genomic_DNA.
DR   Proteomes; UP000054064; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054064};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KFO89539.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054064};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    130    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    199    219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    231    248       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    404    431       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    768    786       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    798    821       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    878    906       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    968    991       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1220   1238       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1259   1281       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1287   1307       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1336   1362       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1460   1484       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1542   1560       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1572   1590       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1602   1622       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1659   1687       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1768   1791       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      136    438       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      514    717       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      768    996       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1005   1213       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1218   1492       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1541   1801       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1805   1849       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      428    473       {ECO:0000256|SAM:Coils}.
FT   COILED      504    524       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2019 AA;  229073 MW;  35DF237C657A0D86 CRC64;
     MAQALLVPPG PESFRYFTRD SLAAIEKRSA EEKAKKPKQE HTDDDDENGP KPNSDLEAGK
     TLPFIYGDIP PGMVSEPLED LDPYYINKKT FIVLNKGKAI FRFSATSALY ILTPFNPIRK
     IAIKILVHSY PFFLIMLIMC TILTNCVFMT MSNPPDWTKN VEYTFTGIYT FESLIKILAR
     GFCLEGFTFL RDPWNWLDFS VILMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI
     VGALIQSVKK LSDVMILTVF CLSVFALIGL QLFMGNLRNK CLQWPPDNST FETTVISYFN
     STVDENGTFV NMTVSTFNWK DYIEDETHFY ILEGQRDALL CGNSSDAGQC PEGYICVKAG
     RNPNYGYTSF DTFSWAFLSL FRLMTQDFWE NLYQLTLRAA GKTYMIFFVL VIFLGSFYLI
     NLILAVVAMA YEEQNQATME EAEQKEAEFQ QMLEQLKKQQ EEAQATAAVA AASVASRDFS
     GVGGLGELLE SSSEASKLSS KSAKERRNRR KKRRQKEMSE AEDKGDIDNF PKSESEDSIR
     RKSFRFSTEG SQLTYDKRFT SPHQSLLSIR GSLFSPRRNS KTSIFSFRGR AKDIGSENDF
     ADDEHSTLED NESRRDSLFV PNRQGERRNS NISQASVSSR MVPALPVNGK MHSTVDCNGV
     VSLVGGPSTL TSPTGQLIPE GTTTETEIRK RRLSSYQISM EMLEDSAARQ RAMSIASILT
     NTMEELEESR QKCPPCWYRF ANTFLIWDCW SPWLKVKHVV NLVVMDPFVD LAITICIVLN
     TLFMAMEHHP MTEQFSSVLS VGNLVFTGIF TAEMVLKIIA MDPYYYFQEG WNIFDGIIVS
     LSLMELGLAN VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK IIGNSVGALG NLTLVLAIIV
     FIFAVVGMQL FGKSYKECVC KISSDCVLPR WHMHDFFHSF LIVFRVLCGE WIETMWDCME
     VAGQTMCLIV FMLVMVIGNL VVLNLFLALL LSSFSSDNLA ATDDDNEMNN LQIAVARIQK
     GIDYVKRKVR EFIQKAFVRK QKKDLEEIKA LEELNNKKDS CVSNHTAVEI NKDLNYLKDG
     NGTTSGVGTG SSVEKYVIDE NDYMSFINNP GLTVTVPIAV GESDFENLNT EEFSSESDME
     ESKQKLNASS SSEGSTVDIA PPGEGEQAEI ESEEALEPEA CFTEGCVQKF PCCQVSIEDG
     KGKIWWNLRK TCYSIVEHNW FETFIVFMIL LSSGALAFED IYIEQRKTIK TMLEYADKVF
     TYIFILEMLL KWVAYGFQIY FTNAWCWLDF LIVDVSLVSL IANALGYSEL GAIKSLRTLR
     ALRPLRALSR FEGMRVVVNA LVGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKFYHCVNT
     TTGEMFDVSD VNNYTQCEEL IKNNQSARWK NVKVNFDNVG AGYLALLQVA TFKGWMDIMY
     AAVDSRDVED QPKYEDNLYM YLYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKISQDIFM
     TEEQKKYYNA MKKLGSKKPQ KPIPRPMNKF QGMVFDFVTK QVFDISIMIL ICLNMVTMMV
     ETDDQSKEME IILSRINLVF IILFTGEFVL KLISLRHYYF TIGWNIFDFV VVILSIVGMF
     LAEMIEKYFV SPTLFRVIRL ARIGRILRLI KGAKGIRTLL FALMMSLPAL FNIGLLLFLV
     MFIYAIFGMS NFAYVKREVG IDDMFNFETF GNSMICLFQI TTSAGWDGLL APILHTPILN
     SGEPDCDPHK DHPGSSVKGD CGNPSVGIFF FVSYIIISFL VVVNMYIAVI LENFSVATEE
     SAEPLSEDDF EMFYEVWEKF DPDATQFIEY SKLSDFAASL DPPLLLAKPN KVQLIAMDLP
     MVSGDRINCL DILFAFTKRV LGESGEMDAL RIQMEDRFMA ANPSKVSYEP ITTTLKRKQE
     EVSAVIIQRA YRRHLLRQKV KKVSSIYNRN KNKEGDGPGI KEIIIDKLNG NSTPEKTDES
     SSTTSPPSYD SVTKPDKEKY EKDKAEKNYK SKDVRENKK
//
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