ID A0A091H2Z8_BUCRH Unreviewed; 1505 AA.
AC A0A091H2Z8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Rho GTPase-activating protein 5 {ECO:0000313|EMBL:KFO89005.1};
GN ORFNames=N320_12777 {ECO:0000313|EMBL:KFO89005.1};
OS Buceros rhinoceros silvestris.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO89005.1, ECO:0000313|Proteomes:UP000054064};
RN [1] {ECO:0000313|EMBL:KFO89005.1, ECO:0000313|Proteomes:UP000054064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO89005.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL519149; KFO89005.1; -; Genomic_DNA.
DR RefSeq; XP_010133267.1; XM_010134965.1.
DR GeneID; 104492407; -.
DR KEGG; brhi:104492407; -.
DR CTD; 394; -.
DR OrthoDB; 5405671at2759; -.
DR Proteomes; UP000054064; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd22220; pseudoGTPaseD_p190RhoGAP-B; 1.
DR CDD; cd04373; RhoGAP_p190; 1.
DR Gene3D; 1.10.10.440; FF domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR002713; FF_domain.
DR InterPro; IPR036517; FF_domain_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039007; pG1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR032835; RhoGAP-FF1.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR045786; RhoGAP_pG1_pG2.
DR InterPro; IPR039006; RhoGAP_pG2.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR46005; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR PANTHER; PTHR46005:SF2; RHO GTPASE-ACTIVATING PROTEIN 5; 1.
DR Pfam; PF01846; FF; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16512; RhoGAP-FF1; 1.
DR Pfam; PF19518; RhoGAP_pG1_pG2; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00441; FF; 4.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF81698; FF domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51676; FF; 4.
DR PROSITE; PS51852; PG1; 1.
DR PROSITE; PS51853; PG2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054064};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 267..325
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 366..420
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 427..481
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 482..548
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 590..763
FT /note="PG1 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51852"
FT DOMAIN 779..944
FT /note="PG2 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51853"
FT DOMAIN 1264..1451
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 949..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1170..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1039
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1250
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1505 AA; 172213 MW; 84BEE1A6071CAFAC CRC64;
MMAKNKEPRP PSYAVSVVGL SGTEKDKGNC GVGKSCLCNR FVRSKADEYY PEHTSVLSTI
DFGGRVVNND HFLYWGDVTQ SGEDGTECRI HVIEQTEFID DQTFLPHRST NLQPYIKRAA
ASKLQSAEKL MYICTDQLGL EQDFEQKQMP EGKLSIDGFL LCIDVSQGCN RKFDDQLKFV
NNLYMQLSKS KKPIIIAATK CDECVDHYLR EVQAFASNKK NLVVVETSAR FNVNVETCFT
ALVQMMDKTR GKPKIIPYLD AYKTQRQLVV TATDKFEKLV QTVRDYHATW KTVSNKLKNH
PDYEEYINLE GTKKAKNTFS KHIEQLKQEH IRKRKEEYIN ALPRALNTLL SNLDEIEHLS
WSEALKLMEK RPDFQSCFVV LEKTPWDETD HIDKVNDRRI PFDLLTTLEA EKVYQNHVQH
LISEKRRVEM KEKFKKTLEK IQFISPGQPW EEVICFVMED EAFKYITDAD SKEVYGRHQR
EIVEKAKEEF QEMLFEHSEL FYDLDLNATP SSDKMSEIHA VLSEEPRYKA LQKLAPDRES
LLLKHIGFVY HPTKETCLSG QNCTDIKVEQ LLANSLLQLD HGRSNLYHDS ANIDKVNLFI
LGKDGLAQEL ANEIRTQSTD DEYALDGKIY ELDLRPVDAK SPYLLTQLWT STFKPHGCFC
VFNSIESLTF IGDCIAKIRA EASQIRRDKY MANLPFTLIL ANQRDSVSKN LPILRHQGQQ
LANKLQCPFV DVPAGTYPRK FNETQIKQAL RGVLEAVKHN FDVVCPVPTI KDLSEADLRI
VMCAMCGDPF SVDLILSPFL DSHSCSAAQA GQNNSLMLDK IIGEKRRRIQ ITILSYHSSI
GVRKDELVHG YILVYSAKRK ASMGMLRAFL SEVQDTIPVQ LVAVTDSQAD FFENEAIKEL
MTEGEHIATE ITAKFTALYS LSQYHRQTEV FTLFFSDVLE KKNMIESSYM SDSTRETTHT
SEDVFPRSPR GSSLDYNYPD SEDDTEGPPP YSPIGDDVRL LPAPSDRSKY RLDMEGNEYP
IHSTPLNCHD HERNHKVPPP IKPKPLVPRT NVKKLDPNLL KTIEAGISKN PRKQPSRVPA
APPEDTDQSD NYAEPIDTLF KHKGFADDIY AVPDDSQNRI IKVRNSIVIN TQGEEENGFS
DRMSKSHGER RPSKYKYKSK TLFSKAKSYY RRTHSDASDD EAFTTSKTKR KGRHRGSEED
PLLSPVETWK GGIDNPAITS DQELDDKKMK KKTQKVKEDK KPKKKTKTFN PPIRRNWESN
YFGMPLQDLV TPEKPIPLFV EKCVQFIEDT GLCTEGLYRV SGNKTDQDNI QKQFDQDHNI
SLESMGVTVN AVAGALKAFF ADLPDPLIPY SLHQELLETS KIMDKTERLH ELKEILKKFH
PVNYDVFKYV ITHLNRVSQQ YKTNFMTADN LSICFWPTLM RPDFENREFL STTKIHQSVI
ETFIQQCQFF FYNGEIVEAP NPVACQPPPS TAVQMVEPMV PLQLPPPLQP QLIQSQLPAD
PLGII
//
