ID A0A091H5U6_9AVES Unreviewed; 464 AA.
AC A0A091H5U6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=inositol-3-phosphate synthase {ECO:0000256|ARBA:ARBA00012125};
DE EC=5.5.1.4 {ECO:0000256|ARBA:ARBA00012125};
DE Flags: Fragment;
GN ORFNames=N303_15339 {ECO:0000313|EMBL:KFO81657.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO81657.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO81657.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO81657.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC EC=5.5.1.4; Evidence={ECO:0000256|ARBA:ARBA00000113};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 1/2. {ECO:0000256|ARBA:ARBA00005117}.
CC -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC {ECO:0000256|ARBA:ARBA00010813}.
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DR EMBL; KL448255; KFO81657.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091H5U6; -.
DR STRING; 55661.A0A091H5U6; -.
DR UniPathway; UPA00823; UER00787.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11510:SF5; INOSITOL-3-PHOSPHATE SYNTHASE 1; 1.
DR PANTHER; PTHR11510; MYO-INOSITOL-1 PHOSPHATE SYNTHASE; 1.
DR Pfam; PF01658; Inos-1-P_synth; 1.
DR Pfam; PF07994; NAD_binding_5; 1.
DR PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Inositol biosynthesis {ECO:0000256|ARBA:ARBA00022550};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760}.
FT DOMAIN 280..393
FT /note="Myo-inositol-1-phosphate synthase GAPDH-like"
FT /evidence="ECO:0000259|Pfam:PF01658"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO81657.1"
FT NON_TER 464
FT /evidence="ECO:0000313|EMBL:KFO81657.1"
SQ SEQUENCE 464 AA; 51114 MW; 048A6885F29FABCA CRC64;
AEPFLVESPD VTYGKDFIEA KYTYSTVHVC KENGVTKVRP CSTRFTFRTG RHVPRLGVML
VGWGGPVLAN KLGLSWMTKT GRKKANYYGS LLQASTVCLG TGPSGDVYVP FRDLLPMVHP
NDIVFDGWDI SSLNLAEAMR RAEKMKPRPS IYIPEFIAAN QEERADNVLC GTMAEQMEQI
RRDIRDFKET SGVDKVIVLW TANTERFCDV VTGLNDTANN LLRAIEQGLE VSPSTLFAVA
SILEGCAYIN GSPQNTFVPG AVELAAQRHV FICGDDFKSG QTKLKSVLVD FLVGAGLKTK
SIVSYNHLGN NDGKNLSAPQ QFRSKEISKS NVVDDTVQAN PILYGPQDKP DHCVVIKYVP
YVGDSKRALD EYTSEIMMGG TNTIVIHNTC EDSLLASPII LDLAILTELC QRITFCTEAD
PEFQGFHSVL SIVGFLCKAP LVPEGTPVVN ALFRQRSCIE NILR
//
