ID A0A091H910_9AVES Unreviewed; 608 AA.
AC A0A091H910;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Low affinity cationic amino acid transporter 2 {ECO:0000313|EMBL:KFO82717.1};
DE Flags: Fragment;
GN ORFNames=N303_02689 {ECO:0000313|EMBL:KFO82717.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO82717.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO82717.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO82717.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143,
CC ChEBI:CHEBI:32682; Evidence={ECO:0000256|ARBA:ARBA00034423};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine(in) = L-lysine(out); Xref=Rhea:RHEA:70935,
CC ChEBI:CHEBI:32551; Evidence={ECO:0000256|ARBA:ARBA00034422};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ornithine(in) = L-ornithine(out); Xref=Rhea:RHEA:71199,
CC ChEBI:CHEBI:46911; Evidence={ECO:0000256|ARBA:ARBA00034450};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC {ECO:0000256|ARBA:ARBA00008572}.
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DR EMBL; KL448317; KFO82717.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091H910; -.
DR STRING; 55661.A0A091H910; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004755; Cat_AA_permease.
DR InterPro; IPR029485; CAT_C.
DR NCBIfam; TIGR00906; 2A0303; 1.
DR PANTHER; PTHR43243:SF35; CATIONIC AMINO ACID TRANSPORTER 2; 1.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
DR PIRSF; PIRSF006060; AA_transporter; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 67..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 556..606
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO82717.1"
FT NON_TER 608
FT /evidence="ECO:0000313|EMBL:KFO82717.1"
SQ SEQUENCE 608 AA; 65805 MW; 6E7E918EE634F179 CRC64;
LPCGPALSFV RCLVRKKNVS GESLEDSKLC RCLSTLDLIA LGVGSTLGAG VYVLAGEVAK
SDSGPSIVVS FLIAALASVM AGLCYAEFGA RVPKTGSAYL YTYVTVGELW AFITGWNLIL
SYIIGTSSVA RAWSGTFDEL LGKQIGHFFS TYFKMNYSGL AEYPDFFAVF LILLLSGLLS
FGVKESAWVN KIFTAINILV LLFVMISGFV KGDVGNWKIS EDYLIHLTAV TENCSTDENV
TSIYGSGGFM PYGFTGTLAG AATCFYAFVG FDCIATTGEE VKNPQKAIPI GIVVSLLVCF
MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVGWGPAKYV VAVGSLCALS TSLLGSIFPM
PRVIYAMAKD GLLFKCLAQI NSKTKTPLVA TLSSGAVAAI MAFLFDLKAL VDMMSIGTLL
AYSLVAACVL ILRYQPNLTY EEPKYSPEKA ALTASERESA VSESQINMIQ ENHFSLQALI
YPSTLPTEQT ATTVNILVGL LACLVCVLSV LTTYGIHSIA NLEPWSTGLL AVLVASFIVT
ILLIQRQPQN QQKVAFMVPL LPFLPSFSIL VNIYLMVQLS GDTWIRFSFW MALGFVIYFA
YGIRHSIE
//
