ID   A0A091HAZ6_BUCRH        Unreviewed;       686 AA.
AC   A0A091HAZ6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
DE   Flags: Fragment;
GN   ORFNames=N320_10664 {ECO:0000313|EMBL:KFO91885.1};
OS   Buceros rhinoceros silvestris.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX   NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO91885.1, ECO:0000313|Proteomes:UP000054064};
RN   [1] {ECO:0000313|EMBL:KFO91885.1, ECO:0000313|Proteomes:UP000054064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO91885.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   EMBL; KL528185; KFO91885.1; -; Genomic_DNA.
DR   RefSeq; XP_010137887.1; XM_010139585.1.
DR   AlphaFoldDB; A0A091HAZ6; -.
DR   GeneID; 104496461; -.
DR   KEGG; brhi:104496461; -.
DR   CTD; 64750; -.
DR   OrthoDB; 5480520at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000054064; Unassembled WGS sequence.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   CDD; cd00201; WW; 3.
DR   Gene3D; 2.20.70.10; -; 2.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR024928; E3_ub_ligase_SMURF1.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   PANTHER; PTHR11254:SF300; E3 UBIQUITIN-PROTEIN LIGASE SMURF2; 1.
DR   PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR   Pfam; PF00632; HECT; 1.
DR   Pfam; PF00397; WW; 3.
DR   PIRSF; PIRSF001569; E3_ub_ligase_SMURF1; 3.
DR   SMART; SM00119; HECTc; 1.
DR   SMART; SM00456; WW; 3.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   SUPFAM; SSF51045; WW domain; 3.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054064};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          90..123
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          184..217
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          230..263
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          352..686
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        654
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001569-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00104"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFO91885.1"
FT   NON_TER         686
FT                   /evidence="ECO:0000313|EMBL:KFO91885.1"
SQ   SEQUENCE   686 AA;  79259 MW;  297E8A19353957D8 CRC64;
     YIGKSDSITI SVWNHKKIHK KQGAGFLGCV RLLSNAINRL KDTGYQRLDL CKLGPNDNDT
     VRGQIVVSLQ SRDRIGTGGQ VVDCSRLFDN DLPDGWEERR TASGRIQYLN HITRTTQWER
     PTRPASEYSS PGRPLSCFVD ENTPITGTNG ATCGQSSDPR LAERRVRSQR HRNYMSRTHL
     HTPPDLPEGY EQRTTQQGQV YFLHTQTGVS TWHDPRVPRD LSNINCEELG PLPPGWEIRN
     TATGRVYFVD HNNRTTQFTD PRLSANLHLV LNRQNQLKDQ QHQQQQQVVA LCQLPDEAEC
     LTVPRYKRDL VQKLKILRQE LSQQQPQAGH CRIEVSREEI FEESYRQVMK MRPKDLWKRL
     MIKFRGEEGL DYGGVAREWL YLLSHEMLNP YYGLFQYSRD DIYTLQINPD SAVNPEHLSY
     FHFVGRIMGM AVFHGHYIDG GFTLPFYKQL LGKPITLDDM ELVDPDLHNS LVWILENDIT
     GVLDHTFCVE HNAYGEIIQH ELKPNGKSIP VTEENKKEYV RLYVNWRFLR GIEAQFLALQ
     KGFNEVIPQH LLKTFDEKEL ELIICGLGKI DVNDWKANTR LKHCTPDSNI VKWFWKAVEF
     FDEERRARLL QFVTGSSRVP LQGFKALQGA AGPRLFTIHQ IDASTNNLPK AHTCFNRIDI
     PPYESYDKLY EKLLTAIEET CGFAVE
//