ID   A0A091HBM2_BUCRH        Unreviewed;       370 AA.
AC   A0A091HBM2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Short-chain dehydrogenase/reductase family 42E member 1 {ECO:0000313|EMBL:KFO92212.1};
DE   Flags: Fragment;
GN   ORFNames=N320_12734 {ECO:0000313|EMBL:KFO92212.1};
OS   Buceros rhinoceros silvestris.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX   NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO92212.1, ECO:0000313|Proteomes:UP000054064};
RN   [1] {ECO:0000313|EMBL:KFO92212.1, ECO:0000313|Proteomes:UP000054064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO92212.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR   EMBL; KL529223; KFO92212.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091HBM2; -.
DR   Proteomes; UP000054064; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU004475};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054064};
KW   Transmembrane {ECO:0000256|RuleBase:RU004475};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT   TRANSMEM        263..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004475"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004475"
FT   DOMAIN          30..260
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFO92212.1"
FT   NON_TER         370
FT                   /evidence="ECO:0000313|EMBL:KFO92212.1"
SQ   SEQUENCE   370 AA;  41415 MW;  BE64B36E6E67057E CRC64;
     FSLGCAIYQK GVDVILFDVM KPLQTVPEGI KFVQGDVCCL SAVEEALRDV ICVFHIASYG
     MSGREQLNRK LIEDVNVKGT ENVIQACKST GVSSLVYTST YNVVFGGQVI ENGDEFLPYL
     PLHLHPDHYS RTKSLAEMKV LAANGAELGS GKGVLRTCAL RPAGIYGPGE QRHLPRIVSY
     IERGLFRFVY GDPHSLVEFV HVDNLVQAHI LGSEALKANK KHIAAGQAYF ISDGRPVNNF
     EFFRPLVEGL GYKFPTCRLP LSLVYFFAFL TEVVHFLVGH VYNFQPLLTR TEVYKTGVTH
     YFSMEKARKE LGYEPRQYSL DEVVEWFRSR GCGPKPTKYT IMHCVRDGGL LLLLIAVLVS
     WFPSTVTFSL
//