ID A0A091HT91_CALAN Unreviewed; 212 AA.
AC A0A091HT91;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Inducible T-cell costimulator {ECO:0000256|ARBA:ARBA00019739};
GN ORFNames=N300_08695 {ECO:0000313|EMBL:KFO98347.1};
OS Calypte anna (Anna's hummingbird) (Archilochus anna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes;
OC Trochilidae; Calypte.
OX NCBI_TaxID=9244 {ECO:0000313|EMBL:KFO98347.1, ECO:0000313|Proteomes:UP000054308};
RN [1] {ECO:0000313|EMBL:KFO98347.1, ECO:0000313|Proteomes:UP000054308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N300 {ECO:0000313|EMBL:KFO98347.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Enhances all basic T-cell responses to a foreign antigen,
CC namely proliferation, secretion of lymphokines, up-regulation of
CC molecules that mediate cell-cell interaction, and effective help for
CC antibody secretion by B-cells. Essential both for efficient interaction
CC between T and B-cells and for normal antibody responses to T-cell
CC dependent antigens. Does not up-regulate the production of interleukin-
CC 2, but superinduces the synthesis of interleukin-10. Prevents the
CC apoptosis of pre-activated T-cells. Plays a critical role in CD40-
CC mediated class switching of immunoglobin isotypes.
CC {ECO:0000256|ARBA:ARBA00025344}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KL217737; KFO98347.1; -; Genomic_DNA.
DR RefSeq; XP_008488717.1; XM_008490495.1.
DR AlphaFoldDB; A0A091HT91; -.
DR STRING; 9244.A0A091HT91; -.
DR GeneID; 103525535; -.
DR OrthoDB; 4570780at2759; -.
DR Proteomes; UP000054308; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031295; P:T cell costimulation; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR039943; ICOS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR20904:SF0; INDUCIBLE T-CELL COSTIMULATOR; 1.
DR PANTHER; PTHR20904; INDUCIBLE T-CELL COSTIMULATOR ICOS; 1.
DR Pfam; PF15910; V-set_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054308};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..212
FT /note="Inducible T-cell costimulator"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001874487"
FT TRANSMEM 155..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..146
FT /note="Immunoglobulin V-set"
FT /evidence="ECO:0000259|Pfam:PF15910"
SQ SEQUENCE 212 AA; 24322 MW; 497448CE334E84A6 CRC64;
MKSVAVTFCV LCFQFEALYG TDSCSLRPCK NTDRLHITDS QVMVELENGN FKFTFPNPQN
VSEFSMTLFK GHEKKGICAL HLSKEKVVPE SNVTYCQTEY SNSSTTFILK NLEKQHIDTY
TYCLEMFLPP PYIDCRLKET YLYIQDKKDC ISMGVMSWII MGLVMFAMIS FVCCVVACCL
RNKDQQCESN SHEYNSEYMP MAAVNAAKKP RI
//
