ID A0A091I476_CALAN Unreviewed; 453 AA.
AC A0A091I476;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 40.
DE SubName: Full=Bone morphogenetic protein 5 {ECO:0000313|EMBL:KFP02263.1};
GN ORFNames=N300_01194 {ECO:0000313|EMBL:KFP02263.1};
OS Calypte anna (Anna's hummingbird) (Archilochus anna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes;
OC Trochilidae; Calypte.
OX NCBI_TaxID=9244 {ECO:0000313|EMBL:KFP02263.1, ECO:0000313|Proteomes:UP000054308};
RN [1] {ECO:0000313|EMBL:KFP02263.1, ECO:0000313|Proteomes:UP000054308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N300 {ECO:0000313|EMBL:KFP02263.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL218093; KFP02263.1; -; Genomic_DNA.
DR RefSeq; XP_008493864.1; XM_008495642.1.
DR AlphaFoldDB; A0A091I476; -.
DR STRING; 9244.A0A091I476; -.
DR GeneID; 103530104; -.
DR CTD; 653; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000054308; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19395; TGF_beta_BMP5; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF139; BONE MORPHOGENETIC PROTEIN 5; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000054308};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..453
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001874722"
FT DOMAIN 333..453
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 316..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 51656 MW; 1B0C66DD791DE8D7 CRC64;
MNLTALKTFV GLLWNCWALV GHAQGGLGDN HVHSSFIYRR LRNHERREIQ REILSILGLP
HRPRPFSPGK QASSAPLFML DLYNAMTNEE DTEELEYSFK GSMAGESRGI RKGYPATPNG
YSRRIQLSRM TPLATQNPPL ASLHDTNFLN DADMVMSFVN LVERDKDFSH QRRHYKEFRF
DLTQIPHGEA VTAAEFRIYK DRSNSRFENE TIQISIYQII KEYPNRDADL FLLDTRKAQA
SDVGWFVFDI TVTSNHWVIN PQNNLGLQLC AETGDGRSIN VKSAGLIGRH GPQSKQPFMV
AFFKASEVLF RSVRAANNKR KNQNRNKSSS HQESSRMPSV GDYNTSEQKQ ACKKHELYVS
FRDLGWQDWI IAPEGYAAFY CDGECSFPLN AHMNATNHAI VQTLVHLMFP DHVPKPCCAP
TKLNAISVLY FDDSSNVILK KYRNMVVRSC GCH
//
