ID A0A091IE24_CALAN Unreviewed; 500 AA.
AC A0A091IE24;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Growth/differentiation factor 5 {ECO:0000313|EMBL:KFO97970.1};
GN ORFNames=N300_03314 {ECO:0000313|EMBL:KFO97970.1};
OS Calypte anna (Anna's hummingbird) (Archilochus anna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes;
OC Trochilidae; Calypte.
OX NCBI_TaxID=9244 {ECO:0000313|EMBL:KFO97970.1, ECO:0000313|Proteomes:UP000054308};
RN [1] {ECO:0000313|EMBL:KFO97970.1, ECO:0000313|Proteomes:UP000054308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N300 {ECO:0000313|EMBL:KFO97970.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL217718; KFO97970.1; -; Genomic_DNA.
DR RefSeq; XP_008504524.1; XM_008506302.1.
DR AlphaFoldDB; A0A091IE24; -.
DR STRING; 9244.A0A091IE24; -.
DR GeneID; 103539771; -.
DR CTD; 8200; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000054308; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19399; TGF_beta_GDF5; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF44; GROWTH_DIFFERENTIATION FACTOR 5; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000054308};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..500
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001875092"
FT DOMAIN 377..500
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 28..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 500 AA; 56114 MW; 60B97BDA621C9FD9 CRC64;
MKILHFLTLL LWHLTWLSLD LVPGALSNSE AGQSNPGSKL GFLKAEGKER NPSARAGTLR
TASYGYSTGT SKARTKSSAA QAGALLAKND EAKKVLPRTA ATEGKVGHLP SRPSGVRTVT
PKVQNLSSKV ALKKTGTSSA DTDSFKTKKT KEPVSQRETK ETFRHPPITP HEYMLSLYRT
LSDAERKGVN GSVKLEAGLA NTITSFIDKG QDERAPTIRK QKYIFDISAL EKDGLLGAEL
RILRKKPSDT WKSHSSGKTS QVKLFSCSTN RQAATLLDSR TVSITDTPKW EVFDIWKLFR
NFKNLVNLCF ELETFDRGRA VDLRSVGFNR TGRQVNEKAL FLVFGRTKKR DLFFNEIKAR
SGQDDKTVYE YLFNQRRKRR APLATRQGKR PTKNLKARCS RKALHVNFKD MGWDDWIIAP
LEYEAYHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS
ANNVVYKQYE DMVVESCGCR
//
