ID A0A091IGY7_CALAN Unreviewed; 1046 AA.
AC A0A091IGY7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Solute carrier family 12 member 4 {ECO:0000313|EMBL:KFP06625.1};
DE Flags: Fragment;
GN ORFNames=N300_03837 {ECO:0000313|EMBL:KFP06625.1};
OS Calypte anna (Anna's hummingbird) (Archilochus anna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes;
OC Trochilidae; Calypte.
OX NCBI_TaxID=9244 {ECO:0000313|EMBL:KFP06625.1, ECO:0000313|Proteomes:UP000054308};
RN [1] {ECO:0000313|EMBL:KFP06625.1, ECO:0000313|Proteomes:UP000054308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N300 {ECO:0000313|EMBL:KFP06625.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; KL218569; KFP06625.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091IGY7; -.
DR STRING; 9244.A0A091IGY7; -.
DR Proteomes; UP000054308; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF46; SOLUTE CARRIER FAMILY 12 MEMBER 4; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000054308};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 85..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 85..261
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 378..656
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 670..787
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 800..1046
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 58..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP06625.1"
FT NON_TER 1046
FT /evidence="ECO:0000313|EMBL:KFP06625.1"
SQ SEQUENCE 1046 AA; 116499 MW; D5F024EF29C23B52 CRC64;
HGNHKENSPF LNNSEAGKGG DYYDRNLALF EEELDIRPKV SSLLGKLVNY TNLTQGVKEH
EEAESTDASK KKVSKSPSMG TLMGVYLPCM QNIFGVILFL RLTWMVGMAG VLQSFLIVLL
CCCCTMLTTI SMSAIATNGV VPAGGSYFMI SRSLGPEFGG AVGLCFYLGT TFAGAMYILG
AIEIFLTYIV PQAAIFHPSG AHDASSAMLN NMRVYGTVFL ILMAVVVFVG VKYVNKFASL
FLACVVISIL SIYAGAIKSI FDPPEFPICM LGNRTLSRDQ FDICAKTVVK DNITVASKLW
ELFCHTTNLT TENCDEYFLM NNVSEIAGIP GVASGVLKEN LWSNYLEKGE ILEKAHHPSV
DVAGQKNSLH LYVLSDISTS FMVLVGIFFP SVTGIMAGSN RSGDLKDAQK SIPVGTILAI
VTTSLVYFSC VLLFGACIEG VVLRDKYGDA VNKNLVVGTL SWPSPWVIVI GSFFSTCGAG
LQSLTGAPRL LQAIAKDNII PFLWIFGHGK ANGEPTWALL LTALIAELGI LIASLDMVAP
ILSMFFLMCY LFVNLACAVQ TLLRTPNWRP RFKYYHWALS FLGMSICLAL MFISSWYYAL
VAMLIAGMIY KYIEYQGAEK EWGDGIRGLS LSAARYALLR LEEGPPHTKN WRPQLLVLLK
LDEDLHVKYP RLLTFASQLK AGKGLTIIGS VIQGNFLETY GEAQAAEQTI KHMMDIEKVK
GFCQVVVANK VREGIAHLIQ SCGLGGMKHN TVVLGWPYGW RQSEDPRSWK TFIGTVRCTT
AAHLALLVPK NVSFYPSNHE RYNEGNIDVW WIVHDGGMLM LLPFLLKQHK VWRKCKMRIF
TVAQMDDNSI QMKKDLATFL YQLRIEAEVE VVEMHNSDIS AYTYERTLMM EQRSQMLRQM
RLTKTERERE AQLVKDRHSV GRLESLYSDE EDEGDPVPEN IQMTWTKEKC DAEKRNRGSA
VGSFRDLISI KPNQSNVRRM HTAVKLNEVI VNRSHDARLV LLNMPGPPKN TDGDENYMEF
LEVLTEGLER VLLVRGGGRE VITIYS
//
