ID A0A091IHR6_CALAN Unreviewed; 1328 AA.
AC A0A091IHR6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 40.
DE RecName: Full=Nuclear receptor coactivator 2 {ECO:0000256|ARBA:ARBA00013484};
DE AltName: Full=Transcriptional intermediary factor 2 {ECO:0000256|ARBA:ARBA00031751};
DE Flags: Fragment;
GN ORFNames=N300_10884 {ECO:0000313|EMBL:KFP08169.1};
OS Calypte anna (Anna's hummingbird) (Archilochus anna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes;
OC Trochilidae; Calypte.
OX NCBI_TaxID=9244 {ECO:0000313|EMBL:KFP08169.1, ECO:0000313|Proteomes:UP000054308};
RN [1] {ECO:0000313|EMBL:KFP08169.1, ECO:0000313|Proteomes:UP000054308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N300 {ECO:0000313|EMBL:KFP08169.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933}.
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DR EMBL; KL218778; KFP08169.1; -; Genomic_DNA.
DR STRING; 9244.A0A091IHR6; -.
DR Proteomes; UP000054308; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:InterPro.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18950; bHLH-PAS_NCoA2_SRC2; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 6.10.140.20; Nuclear receptor coactivator, Ncoa-type, interlocking domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR028822; NCOA2_bHLH.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF2; NUCLEAR RECEPTOR COACTIVATOR 2; 1.
DR Pfam; PF07469; DUF1518; 1.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 1.
DR SMART; SM01151; DUF1518; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000313|EMBL:KFP08169.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054308};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 26..83
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 119..183
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1273..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1307..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..773
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP08169.1"
FT NON_TER 1328
FT /evidence="ECO:0000313|EMBL:KFP08169.1"
SQ SEQUENCE 1328 AA; 143886 MW; 6D6C3DAF3DD5F6C5 CRC64;
KMSGMGENTS DPSRAESRKR KDPDQLGPSP KRSTEKRNRE QENKYIEELA ELIFANFNDI
DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANEDEVQKA DVSSTGQSVI DKDALGPMML
EALDGFFFVV NPEGNVVFVS ENVTQYLRYN QEELMNTSIY SILHVGDHNE FVKILLPKSL
VNGGSWSGDT PRRNSHTFNC RMLVKPVADS EEGHDNQEAH QKYETMQCFA VSQPNSFKED
GEDLQSCLIC VARRAPMKER PLLPSSESFT TRQDLQGKIT SLDTSTMRAA MKPGWEDLVR
RCIQRFHSQH EGEISFAKRH HQEVLRQGLA FSPVYRFSLS DGTIVSAQTK SKLIRSQTTS
EPQLVISLHM LHREQNVCGM NQDLTGQGMG KILNPISSSS PAHQAMCSGN PGQDMTISSN
INFAINGPKE QMGMPAGRFG GSGGMNHVSS IQASTPQGSN YALKMNSPSQ SSPGMNAGQP
NSMLSPRHRV SPGVAGSPRI PPSQFSPAGS LHSPVGVCSS TGNSHNYTNS SLNALQALSE
GHGVSLGSSL ASPDLKMGNL QNSPVSMNPP QLSKMGSLDS KDCFGLYGEQ SEGTTGQAES
GCHSGEQKDS SESNMPPAVS GERPDGQNKL HDGKSQTKLL QLLTTKSDQM EPSPLSSTMG
DVSKDSTGGL PGSGSAHGTS LKEKHKILHR LLQDSSSPVD LAKLTAEATG KELNQESSST
APGSEVTVKQ EPASPKKNNN NALLRYLLDK DDTKDIGLPD IPPKLERLDS KTDPSGSTKL
IAMRTEKEEI SFEPNEQPGS ELDNLEEILD DLQNSQLPQL FPDSRPGAPA GSVDKQAIIN
DLMQLTSDSS PGTAVATQKP AMRISQSSAG TFPPIRTNSP YSVIPQPGLM GRNEGMIGSQ
GTLGNSSTGM IGGNAPRPTM TSGDWGSQTP AVRVTCAPTA SAMNRPVQAG MIRNPTASIP
LRPSNQPGPR QMLPSQVMNM GPSELEMNIG GPQYSQQQAP PNQTAPWPES ILPIDQATFG
SQNRQPFGSS PDDLLCNHPS SESPSDEGAL LDQLYMALRN FDGLEEIDRA LGIPELVSQS
QTVDPEAFPS QDSSILMEQK APVFSQQYAA QAQMAQGSYA PMQDPSFHPM GQRPGYAALR
MQPRPGLRPT GLVQNQPNQL RLQLQHRLQA QQQCLQYESV IETWSANTDY SNGGASIGQV
ALEGALDRWW WFSLQGPINA QMLAQRQREI LSQHLRQRQM GPAGCMPATM SNPRIPQGNA
QQFPFPPNYG ISQQPDPGFT GATTPQSPLM SPRLAHTQSP MIQQTQANPA YQSSTEMNGW
AQGNMGGN
//
