ID A0A091IKZ5_EGRGA Unreviewed; 740 AA.
AC A0A091IKZ5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=[histone H3]-lysine(27) N-trimethyltransferase {ECO:0000256|ARBA:ARBA00012186};
DE EC=2.1.1.356 {ECO:0000256|ARBA:ARBA00012186};
DE Flags: Fragment;
GN ORFNames=Z169_00147 {ECO:0000313|EMBL:KFP08972.1};
OS Egretta garzetta (Little egret).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Ardeidae; Egretta.
OX NCBI_TaxID=188379 {ECO:0000313|EMBL:KFP08972.1, ECO:0000313|Proteomes:UP000053119};
RN [1] {ECO:0000313|EMBL:KFP08972.1, ECO:0000313|Proteomes:UP000053119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Z169 {ECO:0000313|EMBL:KFP08972.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KK500572; KFP08972.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091IKZ5; -.
DR STRING; 188379.A0A091IKZ5; -.
DR Proteomes; UP000053119; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 1.
DR CDD; cd19217; SET_EZH1; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR048358; EZH1/2_MCSS.
DR InterPro; IPR021654; EZH1/EZH2.
DR InterPro; IPR044438; EZH1_SET.
DR InterPro; IPR041343; PRC2_HTH_1.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EZH1; 1.
DR Pfam; PF21358; Ezh2_MCSS; 1.
DR Pfam; PF11616; EZH2_WD-Binding; 1.
DR Pfam; PF18118; PRC2_HTH_1; 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01114; CXC; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KFP08972.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053119};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KFP08972.1}.
FT DOMAIN 498..600
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 607..722
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 171..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP08972.1"
FT NON_TER 740
FT /evidence="ECO:0000313|EMBL:KFP08972.1"
SQ SEQUENCE 740 AA; 84767 MW; A7E144632D5860A7 CRC64;
IYWKRKVKSE YMRLRQLKRF QANMGAKALF VANFAKVHEK TQILNEAWKK LRVQPVQLMK
PVSGHPFLKQ CTVESIFPGF PSQTLYMRTL NTVALVPIMY SWSPLQQNFM VEDETVLCNI
PYMGDEVKEE DETFIEELIN NYDGKVHGEE GSVLISDAVF LELVNALNQY SDEEEEGHND
SEVKQEDGKE ELPVTRKRKR IAVEGNKKCS KKRFPNDMIF TAISSMFPEY GFPDDMKERY
RELTEVSDPN VLPPQCTPNI DGPYGPCAKS VQREQSLHSF HTLFCRRCFK YDCFLHPFHA
TPNVYKRKNR ETKIEPDPCG ADCFLWLEGA KEFAALHNPR SKCSGRRRRR HHVVGASCSN
APASAVAETR EGDSDRDTGN EWASSSSEAN SRCQTPTKQK LSPASSQLFA VETPQEPVEW
TGAEESPFRV FHGTYFNNFC SIARLLGTKT CKQVFQFAVK ESLITKLPTN ELMNTSQKKK
RKHRQVLDKL VLLWAAHCRK IQLKKDNSPT QVYNYQPCDH PEHPCDSSCP CIMTQNFCEK
FCQCNPDCQN RFPGCRCKTQ CNTKQCPCYL AVRECDPDLC LTCGASEHWD CKVVSCKNCS
IQRGLKKHLL LAPSDVAGWG TFIKESVQKN EFISEYCGEL ISQDEADRRG KVYDKYMSSF
LFNLNNDFVV DATRKGNKIR FANHSVNPNC YAKVVMVNGD HRIGIFAKRA IQAGEELFFD
YRYSQADALK YVGIERETDI
//
