ID A0A091IPY6_EGRGA Unreviewed; 743 AA.
AC A0A091IPY6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=ARF GTPase-activating protein GIT2 {ECO:0000313|EMBL:KFP09628.1};
DE Flags: Fragment;
GN ORFNames=Z169_09491 {ECO:0000313|EMBL:KFP09628.1};
OS Egretta garzetta (Little egret).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Ardeidae; Egretta.
OX NCBI_TaxID=188379 {ECO:0000313|EMBL:KFP09628.1, ECO:0000313|Proteomes:UP000053119};
RN [1] {ECO:0000313|EMBL:KFP09628.1, ECO:0000313|Proteomes:UP000053119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Z169 {ECO:0000313|EMBL:KFP09628.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK500663; KFP09628.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091IPY6; -.
DR STRING; 188379.A0A091IPY6; -.
DR Proteomes; UP000053119; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR032352; GIT1/2_CC.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097:SF4; ARF GTPASE-ACTIVATING PROTEIN GIT2; 1.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF16559; GIT_CC; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053119};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 1..110
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 152..184
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 365..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 430..464
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 394..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP09628.1"
FT NON_TER 743
FT /evidence="ECO:0000313|EMBL:KFP09628.1"
SQ SEQUENCE 743 AA; 82952 MW; 9C8EE0B53936497D CRC64;
SFSDPCWASI NRGILICDEC CSVHRSLGRH ISQVRHLKHT PWPPTLLQMV ETLYNNGANS
IWEHSLLDPA SVMSGRRKAS PQDKVHPNKA EFIRAKYQML AFVHRLPCRE DDSVTAKDLS
KQLHSSVRTG NLETCLRLLS LGAQANFFHP EKGNTPLHVA AKAGQTLQAE LLAVYGADPG
TQDSNGKTPV DCARQGGHHE LAERLVEIQY ELTDRLAFYL CGRKPEHKNG QHFVIPQMAD
SSLDLSELAK AAKKKLQSLS NHLFEELAMD VYDEVDRRET DAVWLATQNH STLVTETTVV
PFLPVNPEYS STRNQGRQKL ARFNAHEFAT LVIDILSDAK RRQQGNPLTG SKENVELILK
SISNQHSNES QDNDQPDYDS VASDEDTDLE TNAAKSNRQK SLDSDLSDGP VTAQEYMQVK
NALVASEVKI QQLMKVNINL SDELRIMQKK LQTLQSENTN LRRQATTNIY QVQTGSEYTD
PTNNSSLKRR PSARGSRPMS MYETGSGQKP YLPMGEVTYP EESITRLQPF PPHIGRSAFV
TSSSSLPSFP STLSWSRDES TRRASKLEKQ SSVSESDYDN PTSPLELEET GSGRKGRQRS
VIWQGEGSIP EDADSAPSSS LPSTEDVIRK TEQITKNIQE LLRAAQENKH DSYIPCSERI
HVAVTEMAAL FPKKPKSELV RTSLRLLTSS AYRLQSECKK TLPVETCPTT DIQLVTQQVI
QCAYDIAKAA KQLVTITTKE NNN
//
