ID A0A091IW23_EGRGA Unreviewed; 858 AA.
AC A0A091IW23;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 27.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
DE Flags: Fragment;
GN ORFNames=Z169_07441 {ECO:0000313|EMBL:KFP12894.1};
OS Egretta garzetta (Little egret).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Ardeidae; Egretta.
OX NCBI_TaxID=188379 {ECO:0000313|EMBL:KFP12894.1, ECO:0000313|Proteomes:UP000053119};
RN [1] {ECO:0000313|EMBL:KFP12894.1, ECO:0000313|Proteomes:UP000053119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Z169 {ECO:0000313|EMBL:KFP12894.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362035}.
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DR EMBL; KK501122; KFP12894.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091IW23; -.
DR STRING; 188379.A0A091IW23; -.
DR Proteomes; UP000053119; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF105; SODIUM BICARBONATE COTRANSPORTER 3; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000053119};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 437..459
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 466..485
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 524..547
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 554..572
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 652..670
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 690..707
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 738..757
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 778..802
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 838..857
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 102..360
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 408..858
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..34
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP12894.1"
FT NON_TER 858
FT /evidence="ECO:0000313|EMBL:KFP12894.1"
SQ SEQUENCE 858 AA; 96422 MW; F4AE1013CF1ACFD2 CRC64;
KGHRAVYIGV HVPFGKQGRR RHRHRGHRHH RRKKEKETDR EDGRESPSYD TPSQRVQFIL
GTEDDDEHIP HDLFTEMDEL CFRDGEEYEW KETARWLKFE EDVEDGGDRW SKPYVATLSL
HSLFELRSCI LNGTVMLDMR ANTLDEIADM VLDNMIASGQ LDESIRENVR EALLKRHHHQ
NEKKFSNRIP LVRSFADIGK KHSDPHLLER NAPGNLDTGK SGDVKGTGTG GSRENSTVDF
SKVDMNFMRK IPSGAEASNV LVGEVDFLER PIIAFVRLSP AVLLSGLTEV PVPTRFLFLL
LGPAGKAPQY HEIGRSIATL MTDDVFHDVA YKAKDRNDLL SGIDEFLDQV TVLPPGEWDP
SIRIEPPKSV PSQEKRKVPK FPNGSTPTGE TLKEEGHHAG PELERTGRLF GGLILDIQRK
APFFLSDFKD ALSLQCLASI LFLYCACMSP VITFGGLLGE ATQGRISAIE SLFGASLTGI
AYSLFAGQPL TILGSTGPVL VFEKILFKFC RDYGLSYLSL RTSIGLWTAF LCIVLVATDA
SSLVCYITRF TEEAFAALIC IIFIYEALEK LFHLGEVYAF NMHNDLNKLT LYSCVCSEPE
KPSNETLQAW RNMNKSVENI AWSNLTVSEC VEFRGVFHGS ACSHHGPYIP DVLFWSVILF
FTTFFLSSFL KQFKTKRYFP TKVRSTISDF AVFLTIVVMV LIDYLVGVPS PKLHVPEKFE
PTRKDRGWFI DPLGSNPWWT LLIAALPALL CTILIFMDQQ ITAVIINRKE HKLKKGCGYH
LDLLMVGIML GICSIMGLPW FVAATVLSIS HVNSLKVESE CSAPGEQPKF LGIREQRVTG
LMIFVLMGLS VFMTSVLK
//
