ID A0A091J1E7_EGRGA Unreviewed; 934 AA.
AC A0A091J1E7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Tight junction protein ZO-3 {ECO:0000313|EMBL:KFP14799.1};
DE Flags: Fragment;
GN ORFNames=Z169_12909 {ECO:0000313|EMBL:KFP14799.1};
OS Egretta garzetta (Little egret).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Ardeidae; Egretta.
OX NCBI_TaxID=188379 {ECO:0000313|EMBL:KFP14799.1, ECO:0000313|Proteomes:UP000053119};
RN [1] {ECO:0000313|EMBL:KFP14799.1, ECO:0000313|Proteomes:UP000053119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Z169 {ECO:0000313|EMBL:KFP14799.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; KK501421; KFP14799.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091J1E7; -.
DR STRING; 188379.A0A091J1E7; -.
DR Proteomes; UP000053119; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12028; SH3_ZO-3; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF11; TIGHT JUNCTION PROTEIN ZO-3; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000053119};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 15..102
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 238..315
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 425..479
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 508..576
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 683..783
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 102..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..360
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..922
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP14799.1"
FT NON_TER 934
FT /evidence="ECO:0000313|EMBL:KFP14799.1"
SQ SEQUENCE 934 AA; 102317 MW; 73BF8849591BF153 CRC64;
RVATMEEMVI WEQHTVTLSK DPQRGFGFAV SGGRDHPNRV TGDTAVVVSD VVAGGPAVGR
LQRKDHIVMV NGLSMENVSS SFAIQTLKSC GKTANITLKR SKKVHLPVSK SSPASPTAPR
CYDSDEDYGS HGADPALHRS RDDLDHSQGY DGDSSSERSS GHHRDDRSHH KSVSRSQRRS
QDSSHWRQSP GSGSDRGGYS RHRSANGFSH EGDTNGLALV SGFKRLPRQD VPTKPITSVL
VKQKQSEEYG LKLGSQLFIK HIVESGLAAK DSSLQEGDLI LKINGVASED MSLADTQQLI
ERTEGTLTLL ILRDHRQFLV NIPDIEDSQS DSSRMDDISD IDSDLPPPET SPPPPAAARM
NSPPERRRSN RDPAADTIVD TAQGPDLLEA VEGDGPHTSP AARAACKAGY SADSRVVQFV
KAQSVGLRLA GGNDVGIFVS SVQEGSPADS QGIREGDQIL QVNDTSFQNL TREEAVEYLM
SLPPGEDITL WTQSKQDIYR KMISSNVGDS FYIRTHFDFE KDTPSGLSFT RGDVFHVLDT
MYRGRLGSWL AVRVGKDLQE QDKGVIPNRS RAEQIASLEP VLKATSGANP SGARAEFWKL
RGLRGAKKML RKSREDLSAL TKQGRYPPYE KVVLKEASFK RPVVILGPIA DIAMKKLSTE
LPELFETAPS VPRDGASSKV IKLDSVRQIA EKDKHALLDI TPSAVECLNY MQYYPVVVFC
EPESRQGIKA MRQWLAPDSR KSSRRLYAQA SKMKKYCSHL FTATISLSGS SNTWYEAIKD
IVRTQQSQPV WTGAEQADVA LEDSLDLPNS RSVATSGYLT CDSQANSDYD DTDGEAGAYT
DGEAEDAYDQ PGLARSSEPA QMSPSHSPSE QMGPPTLVRG AGGAEWGDLS LPPIPNRFSS
PREYEHDAVR KRFTRARDDS DEDEGYEWGP ATDV
//
