ID   A0A091J2Y0_EGRGA        Unreviewed;       927 AA.
AC   A0A091J2Y0;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   ORFNames=Z169_06953 {ECO:0000313|EMBL:KFP14050.1};
OS   Egretta garzetta (Little egret).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Ardeidae; Egretta.
OX   NCBI_TaxID=188379 {ECO:0000313|EMBL:KFP14050.1, ECO:0000313|Proteomes:UP000053119};
RN   [1] {ECO:0000313|EMBL:KFP14050.1, ECO:0000313|Proteomes:UP000053119}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Z169 {ECO:0000313|EMBL:KFP14050.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   EMBL; KK501303; KFP14050.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091J2Y0; -.
DR   STRING; 188379.A0A091J2Y0; -.
DR   Proteomes; UP000053119; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF20; ANOCTAMIN-2; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053119};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        293..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        369..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        452..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        498..522
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        542..563
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        669..692
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        720..744
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        819..844
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          3..279
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          282..862
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          42..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..70
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   927 AA;  107087 MW;  94F83DE8FD5BB0BB CRC64;
     MHFRDSKRKV DYVLAYHYRK CFARHPPGAG SPELTHGSAS LALVSNGGTG KGRAEPQRQD
     GDHHAPQEHP GVEVIELGPL DALEEEKRLQ REEYERNLVE AGLEIEKDPE NKSQGLSFVR
     IHAPWQVLSR EAELLKIKMP TKKMYEITEE GGILKTLNEI WCKLTEPLQP QVPQQGNTNM
     KSLSYPFSRE KIYLYNIKDK DTFFDNATRS RIVREILKRT STKARNSMGI GTLIASNVYD
     AAYPLHDGEY EGQNDDMNER KLLYREWARY GVFYKFQPID LIRKYFGEKI GLYFAWLGLY
     TEFLIPSSVV GIIVFLYGCI TIESDIPSKE MCDQRNTFTM CPLCDKFCDY WNLSSACATA
     QASHLFDNPA TVLFSIFMAL WATMFLEQWK RLQMRLSYFW DLTGLEEEEE HPRPEYETKL
     LQKKLKNKNF TTENSNEEEK KKLTWSDRMP GYAANLGLIL FMIMLTFSAV FGVIVYRITT
     AAALSFSTNE TTRSNVRVTV TATAVIINLV VILILDEIYG AVAKWLTEIE VPKTEKTFEE
     RLILKAFLLK FVNSYAPIFY VAFFKGRFVG RPGHYVYVFD GYRMEECAPG GCLMELCIQL
     SIIMLGKQLI QNNLFEIGIP KLKKLFRKLK DERTEPKEMD TNQSKDPQQW DLDYILEPFT
     GLTPEYMEMI IQFGFVTLFV ASFPLAPLFA LLNNIIEVRL DAKKFVTELR RPDTVRAKDI
     GIWYNILSGI GKLSVIINAF VIAVTSDFIP RLMYQYAYSQ NGTMHGFINH TLSYFNVSHL
     KAGTQPENSP FAQDVIFCRF KDYREPPWSQ NQYEFSKQYW AVLSARLAFV ILFQNLVMFL
     SVLVDWMIPD IPKDISEQIK KEKSVLIDFF LKEEHEKLKL IESFIARDKK KHKSGTKGER
     IRAASFCQFN QSRKGSFASF SSQHTEV
//