ID   A0A091JCH4_EGRGA        Unreviewed;       341 AA.
AC   A0A091JCH4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating {ECO:0000313|EMBL:KFP17528.1};
DE   Flags: Fragment;
GN   ORFNames=Z169_04869 {ECO:0000313|EMBL:KFP17528.1};
OS   Egretta garzetta (Little egret).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Ardeidae; Egretta.
OX   NCBI_TaxID=188379 {ECO:0000313|EMBL:KFP17528.1, ECO:0000313|Proteomes:UP000053119};
RN   [1] {ECO:0000313|EMBL:KFP17528.1, ECO:0000313|Proteomes:UP000053119}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Z169 {ECO:0000313|EMBL:KFP17528.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR   EMBL; KK501764; KFP17528.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091JCH4; -.
DR   STRING; 188379.A0A091JCH4; -.
DR   Proteomes; UP000053119; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU004475};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053119};
KW   Transmembrane {ECO:0000256|RuleBase:RU004475};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004475"
FT   DOMAIN          9..259
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFP17528.1"
FT   NON_TER         341
FT                   /evidence="ECO:0000313|EMBL:KFP17528.1"
SQ   SEQUENCE   341 AA;  38123 MW;  06FCC57B2CDB7224 CRC64;
     RQAGKKCTVI GGSGFLGQHM VEQLLEKGYA VNVFDIQKRF DNDRVQFFLG DLCDKEALLP
     ALQGVSVAFH CASPAPSSDN RELFYKVNFM GTKAVIEACK EAGVQKLVLT SSASVVFEGT
     DIKNGSEDLP YAKNPIDYYT ETKILQEKEV LSANDPGNNF FTTAIRPHGI FGPRDPQLVP
     ILIQAAKSGK MKFIIGDGKN LVDFTYVENV VHGHILAAEN LQKDSPLCGK AFHITNDEPV
     PFWAFMSRIL TGLNYDPPKY RIPYWLAYYL ALFLSLVLWL LSPLVTIKPT FTPMRVALAG
     TFHYYSCERA KRDMGYKPVV SLDEAINRTL QSYPHLRRAK A
//