ID A0A091JD14_EGRGA Unreviewed; 2063 AA.
AC A0A091JD14;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
DE Flags: Fragment;
GN ORFNames=Z169_11361 {ECO:0000313|EMBL:KFP18477.1};
OS Egretta garzetta (Little egret).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Ardeidae; Egretta.
OX NCBI_TaxID=188379 {ECO:0000313|EMBL:KFP18477.1, ECO:0000313|Proteomes:UP000053119};
RN [1] {ECO:0000313|EMBL:KFP18477.1, ECO:0000313|Proteomes:UP000053119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Z169 {ECO:0000313|EMBL:KFP18477.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; KK501883; KFP18477.1; -; Genomic_DNA.
DR STRING; 188379.A0A091JD14; -.
DR Proteomes; UP000053119; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00871; PI4Ka; 1.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFP18477.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053119};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1491..1679
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1769..2047
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 211..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP18477.1"
FT NON_TER 2063
FT /evidence="ECO:0000313|EMBL:KFP18477.1"
SQ SEQUENCE 2063 AA; 233600 MW; F556C24DA278F7B3 CRC64;
PSAVFQVQKL LCMCPVDFHG IFQLDERRRD AVIALGIFLI ESDLQHKDNV VPYLLRLLKG
LPKVQWIEES NARKGRGLLP VAENFSFCLV TLLSDVAYRD ASLREQILDA ILQVMQFLLG
MCQTPQMHDK EYLCKYAVPC LIGISRAFGR YSNSEEALLS KLFPKIPPHS LRVPEELEGI
RRRSFNDFRS ILPSSLLTVC QEGTLKRKAS SVSSISQVSP ERAVPPPSSP GGSAIHYFEG
SYLPDGSALD PDYYFSTISS SFSVSPLFNG INNKEFNIPL EMLRQLLNMV KQIVGDSLLK
TLDAVVAEVA ETGANTDLYY KTFSDPLYLA QFKMLRDTLY YMKDLPNSFV KEIHDFVLEQ
FNSSQSELQK ILHDVDRLHN ELSPLKLRCQ ANAACVDLMV WAVKDEQGAE NLCIKLSEKL
QSKTSSKVII AHLPLLICCL QGLGRLCERF PVVVHSVNPS LRDFLVIPSP VLVKLYKYHS
QYHTVGGNDI KISVTNEHSE STLNVMPGKK SQPSMYEQLR DIAIENICRC LKAGLTIDSV
IVEAFLASLS NRLYISQESD KEAHLIPDHT IRALGHIAVA LRDTPKMMEP ILQILQQKFC
QPPSHLDVLI IDQLGCLVIT GNQYIYQEVW NLFQQISVKA SSVVYSATKD YKDHGYRHCS
LAVINALANI AANIQGEHLV DELLMNLLEL FVQLGLEGKR ASERASEKGP ALKASSSAGN
LGVLIPVIAV LTRRLPPIKE AKPRLQKLFR DFWLYSVLMG FAVEGSGLWP EEWYEGVCEI
ATKSPLLTFP SKEPLRSVLQ YNSAMKNDTV TSAELNELRS TIINLLDPPP EVSALINKLD
FAMSTYLLSV YRLEYMRVLR STDQDRFQVM FCYFEDKAIQ KDKSGMMQCV IAVADKVFEA
FLTMMADKPK TKENEEELER HAQFLLVNFN HIHKRIRRVA DKYLSGLVDK FPHLLWSGTV
LKTMLDILQT LSLSLSADIH KDQPYYDIPD APYRITVPDT HEARESIVKD FAARCGMILQ
EAMKWAPSVT KSHLQEYLNK HQNWVSGLSQ HTGLAMATES VLHFAGYNRQ NTTLGATQLT
ERPTCVKKDY SNFMASLNLR NRYAGEVSGM IQFSNATGRS SDLNKLMVKE LNDALELGHT
EFYTQAMFKL TALLISSKDC DPQLLHHLCW GPLRMFNEHG METAIACWEW LLAAKNGIEV
PFMREMAGAW QMTVEQKVGL FSAEQKEADP LAASEESQPR PCPPEVTPHY IWIEFLVQRF
EIAKYCSSDQ IEIFSSLLQR SLSLNIGGAK GSLNRHVAAI GPRFKLLTLG LSLLHADVVP
NATVRNVLRE KIYSTAFDYF RFVGGLFFFL IHSTSHYLCD FFNFPLKVHK FWTAMFSDKK
YLTASQLVPP DNQDTRSNLD INVGSRQQAT QGWINTYPLS SGMSTISKKS GMSKKTNRGT
QLHKYYMKRR TLLLSLLATE IERLITWYNP LSSPELELDQ TGESSVANWR SKYISLSEKQ
WKDNVNLAWS ISPHLAVQLP TRFKNTEAIG TEVTRLVRLD PGAVSDVPEA IKYLVTWHTI
DADAPELSHV LCWAPTDPPT GLSYFSSMYP PHPLTAQYGV KVLRSFPPDA ILFYIPQIVQ
ALRYDKMGYV REYILWAAAK SQLLAHQFIW NMKTNIYLDE EGHQKDPDIG ELLEQLVEEI
TGSLSGPAKE FYQREFDFFN KITNVSAIIK PFPKGDERKK ACLSALSEVK VQPGCYLPSN
PEAIVLDIDY KSGTPMQSAA KAPYLAKFKV KRCGVSELEK EGLRCRSDSI DESAEEGVDS
KKICWQAAIF KVGDDCRQDM LALQIIDLFK NIFQLVGLDL FVFPYRVVAT APGCGVIECI
PDCTSRDQLG RQTDFGMYDY FTRQYGDEST LAFQKARYNF IRSMAAYSLL LFLLQIKDRH
NGNIMLDKKG HIIHIDFGFM FESSPGGNLG WEPDIKLTDE MVMIMGGKME ATPFKWFMEM
CVRGYLAVRP YMDAVVSLVT LMLDTGLPCF RGQTIKLLKH RFSPNMTERE AATFIIKIIQ
NCFLSNRSRT YDMIQYYQND IPY
//
