ID A0A091K4C9_EGRGA Unreviewed; 366 AA.
AC A0A091K4C9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Growth/differentiation factor 10 {ECO:0000256|ARBA:ARBA00040122};
DE AltName: Full=Bone morphogenetic protein 3B {ECO:0000256|ARBA:ARBA00042879};
DE Flags: Fragment;
GN ORFNames=Z169_12786 {ECO:0000313|EMBL:KFP18636.1};
OS Egretta garzetta (Little egret).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Ardeidae; Egretta.
OX NCBI_TaxID=188379 {ECO:0000313|EMBL:KFP18636.1, ECO:0000313|Proteomes:UP000053119};
RN [1] {ECO:0000313|EMBL:KFP18636.1, ECO:0000313|Proteomes:UP000053119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Z169 {ECO:0000313|EMBL:KFP18636.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KK501886; KFP18636.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091K4C9; -.
DR Proteomes; UP000053119; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:InterPro.
DR CDD; cd19394; TGF_beta_GDF10; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR017197; BMP3/BMP3B.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF145; GROWTH/DIFFERENTIATION FACTOR 10; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF037403; BMP3/GDF10; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037403-1};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000053119};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 254..366
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 156..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 264..331
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 293..363
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 297..365
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 330
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP18636.1"
FT NON_TER 366
FT /evidence="ECO:0000313|EMBL:KFP18636.1"
SQ SEQUENCE 366 AA; 42015 MW; 9A11B49B32F8D9FF CRC64;
EFLAQKPLYC FNLTSMQDSE MILAATFHFY ADKRLRHREV FCKRSKNSSC RLLHLPPVLR
LNLIFQSIHQ NSAYGLVKEN ITVFLQRRGA WHAKDISHII KESKRAGELI LCAELDSGEK
QQGFPEQVAS HLPYILVYAN DLAISEPNSV AVTLQRYDPF PSNDGDPNLS PNASTDTRVR
RDTYLSSSIQ NNELPEVDYN SNKYNKHDIW ENAYKSLKPK ASRKDRRRKG QENTETLTKS
QVLNFDEKTM KKARRKQWNE PRICSRRYMK VDFADIGWNE WIISPKSFDA YYCAGACEFP
MPKIVRPSNH ATIQSIVKAV GIIPGIPEPC CVPDKMSSLS VLFLDENKNV VLKVYPNMSV
ETCACR
//