ID A0A091K8B9_EGRGA Unreviewed; 3617 AA.
AC A0A091K8B9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Laminin subunit alpha-5 {ECO:0000313|EMBL:KFP19991.1};
DE Flags: Fragment;
GN ORFNames=Z169_02749 {ECO:0000313|EMBL:KFP19991.1};
OS Egretta garzetta (Little egret).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Ardeidae; Egretta.
OX NCBI_TaxID=188379 {ECO:0000313|EMBL:KFP19991.1, ECO:0000313|Proteomes:UP000053119};
RN [1] {ECO:0000313|EMBL:KFP19991.1, ECO:0000313|Proteomes:UP000053119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Z169 {ECO:0000313|EMBL:KFP19991.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; KK502049; KFP19991.1; -; Genomic_DNA.
DR STRING; 188379.A0A091K8B9; -.
DR Proteomes; UP000053119; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 19.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 17.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 18.
DR Pfam; PF02210; Laminin_G_2; 4.
DR Pfam; PF06008; Laminin_I; 1.
DR Pfam; PF06009; Laminin_II; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 12.
DR SMART; SM00180; EGF_Lam; 20.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 5.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 17.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01248; EGF_LAM_1; 7.
DR PROSITE; PS50027; EGF_LAM_2; 15.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR PROSITE; PS51115; LAMININ_IVA; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000053119};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..201
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 336..380
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 402..448
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 449..494
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 495..539
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 540..584
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 585..630
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 682..734
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1344..1389
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1434..1482
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1483..1533
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1554..1732
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1766..1815
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1816..1871
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1872..1925
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1926..1972
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1973..2019
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2636..2834
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2848..3037
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3044..3212
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3263..3432
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3439..3614
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 2296..2318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3145..3175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3225..3250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2113..2154
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2456..2591
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2296..2311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3146..3160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 356..365
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 402..414
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 425..434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 449..461
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 451..468
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 470..479
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 495..507
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 515..524
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 540..552
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 560..569
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 585..597
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 587..604
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 606..615
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 705..714
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1344..1356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1346..1363
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1365..1374
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1458..1467
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1483..1495
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1485..1502
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1504..1513
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1785..1794
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1842..1851
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1897..1906
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1909..1923
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1945..1954
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1993..2002
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP19991.1"
FT NON_TER 3617
FT /evidence="ECO:0000313|EMBL:KFP19991.1"
SQ SEQUENCE 3617 AA; 396957 MW; F4C02AE6FC2BE2D7 CRC64;
QGQYCDICSS ANSNKAHPIT NAIDGTERWW QSPPLSRGLE FNQVNVTLDL GQLFHVAYVL
IKFANSPRPD LWVLERSTDF GLTYEPWQYF ASSKRDCIEK FGLQTVDRIS KDDHAICTTE
YSRIVPLENG EIVVSLVNGR PGAMNFSYSP LLRNFTKATN IRLRFLQTNT LLGHLMGKAL
RDPTVTRRYY YSIKDISIGG RCVCHGHADV CDAKDPNDPY SCVQLPAEVG TVGRSSPRSC
PGTVIPAITL PERGTAGAGG AQEHPCNCNG HAYDCYYDPE VDRHKASRSH QDKFEGGGVC
IDCQHHTTGI NCERCIPGYY RSPDHPIDSP YICYRCNCES DFTDGTCEDL TGRCYCKPNY
TGEHCDACAE GYLNFPHCYP VPAFAHNDTG EQVLPAGQII NCDCYAGGTE GNACRKDPRV
GMCVCKPNFQ GTHCDRCAPG HYGPSCQPCQ CSGPGQYDGT CDSETGQCLC RTGFEGHSCN
QCAPGYFNYP LCQLCGCSAV GTLPGGCDSV GRCFCRPEFA GPRCEQCSPG HHSYPHCYAC
SCDPRGAVDN NCSPAGQCQC HGNFAGHTCN QCALGFYGYP SCTPCQCSRE GSLHSTCDQG
TGQCSCRPRV TGLRCDSCLP GTYGFPHCEA GSCNPAGLVT ADPSLAPGSC ACRAYVEGPA
CDRCKPLYWN LTPENPYGCM SCKCDTRGTI SGIAECQQGD GQCFCKPNIC GQFCSACKDG
YFNMENANYF GCQGCRCDVG GSLGPSCEER SGACRCRQST RGPTCTQPAR DHYFPDLHHL
KFELEEGTTP AGRAVRFGYN PLEFEGFSWR GYAQMSSIQP KVVVTLNVTS PDLFRLVFRY
VSRGPASVEG RVSVVEEGRF NVCGNCTEQT KQIVFAPSTE PAFVTVPQNS FGEPFVLNPN
TWSLVVEAEG VLLDYLVLLP SSYYEAPILQ LKVTEPCTYQ PAPEQATQNC LLYKYLSVDG
FPAASGVDAV CRLDNRLPRA CPTEQLSPSH PRMATCSGSD VEVQLSLPIA QPGKYVLVVE
YANTNALQMV GVAVSSPHLA MQQATFIFYP CVYSFLCRGV AVDSQGRMAT FELTSEATIR
FASDLADFFL HKVYLVPAAR FTMDFIEPKV HCISVHGTFS SNSSSCVPSR FLKLSQSIVL
EGGQALPIAP DVPLAQAVHV APAGVPVEAA PRPPTAVDPT AELILLQPPQ AAVVFNSRIQ
TLGRYAFILH YYQPNHPTFP VEVLINGGRI WQGQTNATFC PHGYGCRSLV VSEDQIILDV
TDNDLTVVVR VPEGKELWLD YILVVPEDSY SSQYLQEEPL DKSYDFISSC GVNSFYINPS
TSSRFCRDSA ISLSLFYNNG AQPCRCHEAG ARGSQCEPFG GQCPCKSNVI GRECSRCATG
YWGFPNCRPC DCGTRLCDEV TGQCICPPHT LKPECVVCEP QTFGCHPLIG CEDCNCSRPG
VQELTEPGCD VDSGQCRCKP NIVGRQCDLC APGFYHYPSC RRCDCHQAGT EASVCDPVTG
QCHCKENVEG PRCDQCRLGT FSLDASNPKG CTKCFCFGAT DRCRSAEKHR AEFVDMNGWL
LLSSDRQEVP TTLSLREQLL RADLRNLPDA YQELYWVAPS SYLGDRVSSY GGHLRYELHS
DPRRGDVFIP MESRPDVILK GNQMSIMFLE GTYPSPGEAH EGQLQLVEGN FRHTETHNPV
SREELMMVLA NLEQLQIRAL FSQLSSSVSL RHVVLEMATD AATGIRASNV ELCFCPANYQ
GDSCQECAPG YYRDTKGLFL GKCIPCHCNG HSDQCLPGSG ICLNCQHNTE GDHCERCKDG
YVGSHSAEEP LQCVGCPCPL SVASNNFAVG CVHKGSNTQC LCKPGYAGPN CERCAPGYYG
NPLVIGSSCQ PCDCSGNTDP NMLFSSCDPL TGACTGCMHH TAGARCEVCA PGYFGDAVAA
KNCTQCNCSP CGTESCHPQT GQCFCKTGVT GQHCDHCEEG YYGFEGCSGC RRCDCDIGAV
GSDCHTQTGQ CRCLPGVSGL RCQQCAPGYW GFSEGGCTKC ECRGGSCDPR TGECTCSNGL
TGKQCDACVH QYEIPVANGA DSMRCEVCDS CVLLLLEDLQ SIEMSFPSIR SQLVNLNASS
IAWARLHGLN STMATVANQL REYQRAMNKV RQRADELEDE SVDLTQDLNA LQHKMTMTHR
EANRIEQHTR ETHQRGEQLL LNIQSIQKGI ADLVRQMARF GAANASTTST EEFRQKMAEV
ERMLREMKER SLGSQEELAR REHEEAQKLL HQVKSELYAR WESNQDLVSS IQDRLAQHSS
QLMDLRDALN EAVNKTRQTE DLNSLNRNNL EESQQKSREL QKQHVLVQET LRMAQDSLAR
ISDFLQKMES AKEVYEKLAA LLDGAKLPLT ERVKKFSPAS SKIPIVEQAE EHARLLDELA
RNLSSIIQGT NQDGFIQRAI DASNAYASII EAVKKAERAA HDADEAAGEA LMSVIAENLG
AISKELKRNS SNLEEAVRRE QRKLNEAIKG TLQTAKDKLA GLRVKKEQLL SQLQSVQDVL
GRDQEDTKET IQNAKAAAAE ANETAARVED SLSTMKKNLD EWKDQYGDLR NEDLNQAVQD
ARKSVSSLES TIPLLLGKLS SLENRRNKNA TVSENIVRIR QLITQARNAA SKVKVPMKFN
GSSGVQVRLP SNLQDLAAYT SLKFYIQNPE PRSRQRRQDG AEEGRFVLYL GSREASGDYL
GIVLKDRRVQ WVYKLGDEEP ASLTVDEDIG EQFATISINR ILQYGQMSVI VERQTVHETK
GDGVAKGEQG LLNLDPRNVV FYVGGYPSSF TPPPTLRYPN YLGCLELDTL NEEVVSLYNF
QHTFQVDTTT EKPCARSKST GDPWLTDGSY FDGTGYAEIK FESQFGTTKR FEQEIRVVSY
NGILFFLENQ AGCGAERPSC LSQGQFLCLA IRDGKLVLYY DFSTGLEMAK PSSNSSSLTI
SSTTNKAIQI FLLKMNNKKR ILVRLERLTI FMVEQENSLE NAVSYYLGGV PPAVLPPSLK
ALFPMGGPIR GCMKGLKALG KYVDLKRMST VGVSYGCTSD LLVARSVSVH GHGYLTLALK
DVPGLRDFYS GFSFRTSQQE GLLYHHATQE GTCQVSLQRG QLTLNLLETE VTTENTYADD
RTHYAAFYSD PRGVRLYVDD ELQDTAAGTG SRRRQRRQDG RPLFQLGGSP EPGAPSSLMG
CIGNVFVKRT SEPQMVVDLQ QNVESVNVTM SCPLGEQPQQ LRVTLKKDRR KPKVPGKPAS
KDRRHDGDGL CRLHPQPHAA RGTFRFGGSP SSRWEFEEIP ASFGWRSHFS LEVKLNSSSG
LLFYVAGKRG TFMALFVSNG HFVFLVDIGG RRLRIRSKDK YRDRRWHTVF FSRDQSRAQL
VIDGLRAQDA AVATAALFVA RTPLYVGGIP AGKAKAHIPV ASASSFDGCL RNLQLDGRPL
GPPSRTFGVT QCYEGALESG VFFAAEGGSV ILADAVATEQ DLEVTLEVRP RSASGLIFHL
GMRRSHHLLL YMEEMKVTVR ANAGADEFSA SVTYPSLCDG QWHTIAVTKW KNIIQVDVDT
EGNYTAGPSQ PPAPSTRATF SVGGLLEPDK AGTVPLLPPL PHYVGCIRNL VINRSHVDLP
RAGTVRGSVG LKGCPVL
//
