ID A0A091KDU2_COLST Unreviewed; 1072 AA.
AC A0A091KDU2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Rho GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00014465};
DE AltName: Full=Rho-type GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00030675};
DE AltName: Full=START domain-containing protein 12 {ECO:0000256|ARBA:ARBA00032733};
DE AltName: Full=StAR-related lipid transfer protein 12 {ECO:0000256|ARBA:ARBA00030542};
DE Flags: Fragment;
GN ORFNames=N325_11758 {ECO:0000313|EMBL:KFP34258.1};
OS Colius striatus (Speckled mousebird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coliiformes; Coliidae; Colius.
OX NCBI_TaxID=57412 {ECO:0000313|EMBL:KFP34258.1, ECO:0000313|Proteomes:UP000053615};
RN [1] {ECO:0000313|EMBL:KFP34258.1, ECO:0000313|Proteomes:UP000053615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N325 {ECO:0000313|EMBL:KFP34258.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; KK552735; KFP34258.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091KDU2; -.
DR Proteomes; UP000053615; Unassembled WGS sequence.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04375; RhoGAP_DLC1; 1.
DR CDD; cd09591; SAM_DLC1; 1.
DR CDD; cd08908; START_STARD12-like; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659:SF2; RHO GTPASE-ACTIVATING PROTEIN 7; 1.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000053615}.
FT DOMAIN 624..830
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 871..1043
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 138..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP34258.1"
FT NON_TER 1072
FT /evidence="ECO:0000313|EMBL:KFP34258.1"
SQ SEQUENCE 1072 AA; 120655 MW; B286835BBF3BC0AA CRC64;
ACDWLRAAGF PQYAQLYEDL LFPIDIALVK REHDFLDRDA IEALCRRLNT LNKCAVMKLE
ISPHRKRSED SDEDEPCAIS GKWTFQRDSK RWSRLEEFDV FPPKPDLNTS SLEAPHLTNT
ASRESVLTDL SERQEVASIL STSSTSSHQP TLQSEASTTR TNSVVSVCSS SNFVANDDSF
SSLPSPRELN SFSFNTKANE KNTKSKTKSL LKRMESLKIK SSHHSKSKAP SKLGLIISGP
ILQEGMDEDK LKQLNCVEIS ALNGNHISLP MVRKRSVSNS TQTSSSSSQS ETSSAVSTPS
PVTRTRSLSA YNKRVGMYLE GFDPFNQSTF SDVMEQNFKN RGSFAEDTVF FIPEDHKPGT
FPKALSNGNF SPTEGNASVN WRTGSFHGHG HLALRRENSG DSSKELGMGK RRNSSSSVSS
RLSIYDNVPG SILYSSTSDL ADLENEDIFP ELDDILYHVK GMQRIVNQWS EKFSDEGDSD
SALDSISPCP SSPKQIHLDV DNDRTTPSDL DSTGNSLIET EEPTGMQDRR DSGVGASLTR
SSRHRLRWHS FQSSHRPSLS SASLQINSQS VTQMNLLQKY SLLKLTALLE KYTPSNKHGF
SWAVPKFMKR IKVPDYKDRN VFGVPLQVNV QRTGQPLPQS IQQAMRYLRN HCLDQVGLFR
KSGVKSRIQA LRQMNESSAD SVNYEGQSAY DVADMLKQFF RDLPEPLMTN KLSETFLQIY
QYVPKDQRLQ AIKAAIMLLP DENREVLQIL LYFLSDVTAA VKENQMTPTN LAVCLAPSLF
HLNTLKRENS SPRVMQRKPS LGKPDQKDLN ENLAATQGLA HMIAECKKLF QIPEEMSRGR
NSYTEQDLRP LSLEELRGGS SPAENHCYLQ DCVDDLFKEM KEKFKGWVSC STSEQAELAY
KKVCEGPPLR LWKTTIEIPA TPEDILNRLL KEQHLWDEDL IDSKVIEPLD SQTDIYQYVQ
NSMAPHPARD FVVLRTWRTN FPKGACVLLA TSVDHDRAPV AGVRVNVLLS RYLIEPCGSG
KSKLTYMCRI DLRGHMPEWY TKSFGHLCAS EVVKIRDSFS HQSLESKEIK SR
//
