ID A0A091KHB4_9GRUI Unreviewed; 339 AA.
AC A0A091KHB4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Acetylserotonin O-methyltransferase {ECO:0000256|ARBA:ARBA00040730};
DE EC=2.1.1.4 {ECO:0000256|ARBA:ARBA00039116};
DE AltName: Full=Hydroxyindole O-methyltransferase {ECO:0000256|ARBA:ARBA00043054};
DE Flags: Fragment;
GN ORFNames=N324_04495 {ECO:0000313|EMBL:KFP38550.1};
OS Chlamydotis macqueenii (Macqueen's bustard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Otididae; Chlamydotis.
OX NCBI_TaxID=187382 {ECO:0000313|EMBL:KFP38550.1, ECO:0000313|Proteomes:UP000053330};
RN [1] {ECO:0000313|EMBL:KFP38550.1, ECO:0000313|Proteomes:UP000053330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N324 {ECO:0000313|EMBL:KFP38550.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the transfer of a methyl group onto N-
CC acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
CC {ECO:0000256|ARBA:ARBA00037645}.
CC -!- PATHWAY: Aromatic compound metabolism; melatonin biosynthesis;
CC melatonin from serotonin: step 1/2. {ECO:0000256|ARBA:ARBA00037926}.
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DR EMBL; KK740516; KFP38550.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091KHB4; -.
DR Proteomes; UP000053330; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0030187; P:melatonin biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11746:SF327; ACETYLSEROTONIN O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Melatonin biosynthesis {ECO:0000256|ARBA:ARBA00043260};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KFP38550.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053330};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:KFP38550.1}.
FT DOMAIN 6..94
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 111..320
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 249
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP38550.1"
FT NON_TER 339
FT /evidence="ECO:0000313|EMBL:KFP38550.1"
SQ SEQUENCE 339 AA; 38008 MW; 02814A509201A7CC CRC64;
DYPQIILQYS SGFLVSKVMF TACELGVFDL LLESGEPLSS DAIAARLGTS TMGMERLLDA
CVGLKLLAVE LTQEGALYRN TEISNIYLTK SSPKSQYHIM MYYSNTVYLC WHYLADAVRE
GRNQYERAFG ISSKDPFGAM YRSEEEMLKF MAGQNSVWSI CGRDVLAAFD LSPFTQIYDL
GGGGGALARE YVSLYPHSTI TIYDLPKVVQ VAKEQFVPPE ERRITFHEGD FFNDSIPEAE
LYILSKILHD WDDDKCRQLL AKVYKACKPG GGVLLVESLL NEDRSGPLET QLYSMNMLVQ
TEGKERTAAE YSKLLEAAGF GEIQVKRTGK LYDAVLGRK
//
