ID A0A091KHL9_EGRGA Unreviewed; 248 AA.
AC A0A091KHL9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 13-SEP-2023, entry version 23.
DE RecName: Full=Thymidylate synthase {ECO:0000256|ARBA:ARBA00015931};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
DE Flags: Fragment;
GN ORFNames=Z169_04920 {ECO:0000313|EMBL:KFP23226.1};
OS Egretta garzetta (Little egret).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Ardeidae; Egretta.
OX NCBI_TaxID=188379 {ECO:0000313|EMBL:KFP23226.1, ECO:0000313|Proteomes:UP000053119};
RN [1] {ECO:0000313|EMBL:KFP23226.1, ECO:0000313|Proteomes:UP000053119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Z169 {ECO:0000313|EMBL:KFP23226.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004992}.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR EMBL; KK502398; KFP23226.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091KHL9; -.
DR STRING; 188379.A0A091KHL9; -.
DR UniPathway; UPA00575; -.
DR Proteomes; UP000053119; Unassembled WGS sequence.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548:SF2; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Reference proteome {ECO:0000313|Proteomes:UP000053119};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 3..248
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 130
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP23226.1"
FT NON_TER 248
FT /evidence="ECO:0000313|EMBL:KFP23226.1"
SQ SEQUENCE 248 AA; 28513 MW; 21B1EF9C0B6FD317 CRC64;
SFSDQFPLLT TKRVFWKGVL EELLWFIKGS TNAKELSAKG VKIWDANGSR EFLDKQGFST
REEGDLGPVY GFQWRHFGAE YKDMHTDYSN QGVDQLQKVI ETIKTNPDDR RIIMCAWNPK
DISLMALPPC HALCQFYVLN GELSCQLYQR SGDMGLGVPF NIASYSLLTY MIAHVTGLKP
GEFIHTLGDA HIYLNHVEPL KVQLQREPRP FPKLRILRKV EDISDFKAED FQIEDYNPHP
PIKMEMAV
//