ID A0A091KMZ6_COLST Unreviewed; 772 AA.
AC A0A091KMZ6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPB {ECO:0000256|ARBA:ARBA00014343};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=DNA excision repair protein ERCC-3 {ECO:0000256|ARBA:ARBA00032205};
DE Flags: Fragment;
GN ORFNames=N325_02757 {ECO:0000313|EMBL:KFP29139.1};
OS Colius striatus (Speckled mousebird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coliiformes; Coliidae; Colius.
OX NCBI_TaxID=57412 {ECO:0000313|EMBL:KFP29139.1, ECO:0000313|Proteomes:UP000053615};
RN [1] {ECO:0000313|EMBL:KFP29139.1, ECO:0000313|Proteomes:UP000053615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N325 {ECO:0000313|EMBL:KFP29139.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; KK534912; KFP29139.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091KMZ6; -.
DR Proteomes; UP000053615; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:KFP29139.1};
KW Helicase {ECO:0000313|EMBL:KFP29139.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000313|EMBL:KFP29139.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053615}.
FT DOMAIN 316..477
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 531..691
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP29139.1"
FT NON_TER 772
FT /evidence="ECO:0000313|EMBL:KFP29139.1"
SQ SEQUENCE 772 AA; 87903 MW; 30E99318F8D83921 CRC64;
DKKKSKKRHY DEDDDDEDEA PGKESQEAVP AGKQVEDSGT KVDEYGAKDY RQQMPLKVDH
ASRPLWVAPD GHIFLEAFSP VYKYAQDFLV AIAEPVCRPT HIHEYKLTAY SLYAAVSVGL
QTSDITEYLQ KLSKTGVPDG IIQFIKLCTV SYGKVKLVLK HNRYFVESTH PDVIQQLLQD
HVIKDCRLRN AEGEETELIT ETFTSKSAIS KSSESGSGPS TSQGTDAQNK PDVPADLFEF
YEQMDKDEEE EEETQTVSFE VKQEMIEELQ KRCIHLEYPL LAEYDFRNDS VNPDINIDLK
PTAVLRPYQE KSLRKMFGNG RARSGVIVLP CGAGKSLVGV TAACTVRKRC LVLGNSAVSV
EQWKAQFKMW STIDDSQICR FTSDAKDKPI GCSIAISTYS MLGHTTKRSW EAERVMEWLK
SQEWGLMILD EVHTIPAKMF RRVLTIVQAH CKLGLTATLV REDDKIVDLN FLIGPKLYEA
NWMELQNSGY IAKVQCAEVW CPMSPEFYRE YVAIKTKKRI LLYTMNPNKF RACQFLIKFH
ERRNDKIIVF ADNVFALKEY AVRLGKPYIY GPTAQGERMQ ILQNFKHNPK INTIFISKVG
DTSFDLPEAN VLIQISSHGG SRRQEAQRLG RVLRAKKGMV AEEYNAFFYS LVSQDTQEMA
YSTKRQRFLV DQGYSFKVIT KLAGMEEEEL SFSTKEEQQQ LLQKVLQASD LDAEEEVVAG
EYGSKSAQVS RRTGTMSSMS GADDTVYMEY HTSRSKASAN KHIHPLFKRF RK
//
