ID A0A091KP63_9GRUI Unreviewed; 933 AA.
AC A0A091KP63;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Extracellular calcium-sensing receptor {ECO:0000256|ARBA:ARBA00039746};
DE Flags: Fragment;
GN ORFNames=N324_10441 {ECO:0000313|EMBL:KFP41822.1};
OS Chlamydotis macqueenii (Macqueen's bustard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Otididae; Chlamydotis.
OX NCBI_TaxID=187382 {ECO:0000313|EMBL:KFP41822.1, ECO:0000313|Proteomes:UP000053330};
RN [1] {ECO:0000313|EMBL:KFP41822.1, ECO:0000313|Proteomes:UP000053330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N324 {ECO:0000313|EMBL:KFP41822.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; KK751182; KFP41822.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091KP63; -.
DR Proteomes; UP000053330; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15282; 7tmC_CaSR; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF358; EXTRACELLULAR CALCIUM-SENSING RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFP41822.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053330};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 550..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 770..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 550..814
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 830..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP41822.1"
FT NON_TER 933
FT /evidence="ECO:0000313|EMBL:KFP41822.1"
SQ SEQUENCE 933 AA; 104768 MW; 79736E6FCC6FB9F7 CRC64;
RYNFRGFRWL QAMIFAIEEI NSSPTLLPNM TLGYRIFDTC NTVSKALEAT LSFVAQNKID
SLNLDEFCNC SEHIPSTIAV VGATGSGIST AVANLLGLFY IPQVSYASSS RLLSNKNQFK
SFLRTIPNDE HQATAMADII EYFRWNWVGT IAADDDYGRP GIEKFREEAE ERDICIDFSE
LISQYSDEEE IQQVVEVIQN STARVIVVFS SGPDLEPLIK EIVRRNITGK IWLASEAWAS
SSLIAMPEFF RVIGSTIGFA LKAGQIPGFR EFLQKVHPKK STNNGFAKEF WEETFNCYLP
DGSKNSPTST SFHKGHEEGL GAGNGTAAFR PPCTGDENIT NVETPYMDYT HLRISYNVYL
AVYSIAHALQ DIYTCTPGKG LFTNGSCADI KKVEAWQVLK HLRHLNFTNN MGEQVDFDEF
GDLVGNYSII NWHLSPEDGS VVFEEVGHYN VYAKKGERLF INENKILWSG FSKEVPFSNC
SRDCLPGTRK GIIEGEPTCC FECVDCPDGE YSDETDASAC DKCPEDYWSN ENHTSCIPKQ
IEFLSWTEPF GIALTLFAVL GIFLTSFVLG VFTKFRNTPI VKATNRELSY LLLFSLLCCF
SSSLFFIGEP QNWTCRLRQP AFGISFVLCI SCILVKTNRV LLVFEAKIPT SLHRKWWGLN
LQFLLVFLCT FVQIVICVIW LYTAPPSSYR NHELEDEIIF ITCHEGSLMA LGFLIGYTCL
LAAICFFFAF KSRKLPENFN EAKFITFSML IFFIVWISFI PAYASTYGKF VSAVEVIAIL
AASFGLLACI FFNKVYIILF KPSRNTIEEV RCSTAAHAFK VAARATLRRS NVSRKRSNSL
GGSTGSTPSS SISSKSNHED PFPLPASAER QRQQQRGCKQ KVSFGSGTVT LSLSFEEPQK
NAMANRNAKH RNSLEAQNSD DSLMRHRALL PLQ
//
